女性的生殖因素与皮肤黑色素瘤

Reproductive factors and melanoma of the skin among women.

作者信息

Wyshak G, Frisch R E, Albright N L, Albright T E, Schiff I

机构信息

Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts.

出版信息

Int J Dermatol. 1989 Oct;28(8):527-30. doi: 10.1111/j.1365-4362.1989.tb04606.x.

DOI:10.1111/j.1365-4362.1989.tb04606.x

PMID:2583891

Abstract

A higher risk of reproductive system disorders, (which include benign tumors, endometriosis, dilation and curettage, hysterectomy, and other disorders requiring gynecologic biopsies) exist among women with cutaneous melanoma as compared to women with skin cancers: The odds ratio (OR) is 3.2, 95% confidence limits (1.0, 10.1), p = 0.049; as compared to a random sample of women with no melanoma or skin cancers, the OR is 3.9, 95% confidence limits (1.2, 12.4), p = 0.021. Confirming the observations of others, the authors found that melanoma was associated with red hair. The data also confirmed the finding that melanoma is associated with significantly fewer pregnancies. The mean numbers of pregnancies in the melanoma group is 1.83 +/- 1.6 (mean and standard deviation) compared to 2.99 +/- 1.9 in the skin cancer group and 2.93 +/- 1.9 in the random sample (p less than or equal to 0.05).

摘要

与患有皮肤癌的女性相比，患有皮肤黑色素瘤的女性患生殖系统疾病（包括良性肿瘤、子宫内膜异位症、刮宫术、子宫切除术以及其他需要进行妇科活检的疾病）的风险更高：优势比（OR）为3.2，95%置信区间（1.0，10.1），p = 0.049；与无黑色素瘤或皮肤癌的女性随机样本相比，OR为3.9，95%置信区间（1.2，12.4），p = 0.021。作者证实了其他人的观察结果，发现黑色素瘤与红发有关。数据还证实了黑色素瘤与怀孕次数显著减少有关这一发现。黑色素瘤组的平均怀孕次数为1.83±1.6（均值和标准差），而皮肤癌组为2.99±1.9，随机样本组为2.93±1.9（p≤0.05）。