Department of Chemistry, School of Science and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiaotong University, Xi'an 710049, China.
Org Lett. 2015 Apr 17;17(8):1998-2001. doi: 10.1021/acs.orglett.5b00754. Epub 2015 Apr 3.
A novel transition-metal-free tandem radical thiocyanooxygenation of olefinic amides with potassium thiocyanate has been developed under mild conditions. This method allows a reliable and practical access to diverse SCN-containing heterocycles bearing a wide range of functional groups in good to excellent yields. Furthermore, this tandem reaction provides a simple method for the construction of C-O and C-S bonds in one step.
一种新型的过渡金属自由基串联硫氰基氧合反应，用于烯烃酰胺与硫氰酸钾在温和条件下反应。该方法能够以良好至优秀的收率，可靠且实用地获得具有广泛功能基团的各种含 SCN 的杂环化合物。此外，该串联反应提供了一种一步构建 C-O 和 C-S 键的简单方法。
