微小RNA-889通过DAB2IP促进食管鳞状细胞癌的增殖。
miR-889 promotes proliferation of esophageal squamous cell carcinomas through DAB2IP.
作者信息
Xu Yanting, He Jiangtu, Wang Yue, Zhu Xinyi, Pan Qiuhui, Xie Qiuling, Sun Fenyong
机构信息
Department of Clinical Laboratory Medicine, Tenth People's Hospital of Tongji University, Shanghai 200072, China.
Department of Central Laboratory, Tenth People's Hospital of Tongji University, Shanghai 200072, China.
出版信息
FEBS Lett. 2015 Apr 28;589(10):1127-35. doi: 10.1016/j.febslet.2015.03.027. Epub 2015 Apr 1.
MicroRNAs have been reported to play critical roles in various cancers, but there has been no study on the role of miR-889 in cancers. Here, we report that over-expression of miR-889 leads to rapid proliferation of EC109 and EC9706 cells in vitro and in vivo by inducing cells into S-phase. Using bioinformatics methods, DAB2IP was further confirmed to be a direct target of miR-889. In addition, the expression of DAB2IP, which was negatively correlated with that of miR-889, was significantly associated with clinicopathological features of ESCC patients. In conclusion, miR-889 is an important regulator in ESCC and both miR-889 and DAB2IP may serve as promising biomarkers and therapeutic targets in patients with ESCC.
据报道，微小RNA在多种癌症中发挥关键作用，但尚无关于miR - 889在癌症中作用的研究。在此，我们报告miR - 889的过表达通过诱导细胞进入S期，导致EC109和EC9706细胞在体外和体内快速增殖。使用生物信息学方法，进一步证实DAB2IP是miR - 889的直接靶标。此外，与miR - 889表达呈负相关的DAB2IP表达与ESCC患者的临床病理特征显著相关。总之，miR - 889是ESCC中的重要调节因子，miR - 889和DAB2IP均可能作为ESCC患者有前景的生物标志物和治疗靶点。
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