天然萘二酮及其结构相关类似物对三种蚊虫的杀幼虫活性
Larvicidal activity of naturally occurring naphthalenedione and its structurally related analogs against three mosquito species.
作者信息
Jeon Ju-Hyun, Kim Min-Gi, Lee Hoi-Seon
机构信息
Department of Bioenvironmental Chemistry, College of Agriculture and Life Sciences, Chonbuk National University, Jeonju 561-756, Republic of Korea.
出版信息
J Am Mosq Control Assoc. 2015 Mar;31(1):71-6. doi: 10.2987/14-6438.1.
The objective of this study was to determine the larvicidal activity of an active compound isolated from Cercis chinensis heartwood and its structurally related analogs against 4th-stage Aedes aegypti, Culex pipiens pallens, and Ae. togoi. The larvicidal compound of C. chinensis was isolated with the use of various chromatographic techniques and identified as analogs of 1,4-naphthalenedione. Based on the median lethal concentration (LC(50)) values of commercially procured analogs against Ae. aegypti larvae, the most toxic analog was 2-bromo-1,4-naphthalenedione (1.19 µg/ml); followed by 5-hydroxy-1,4-naphthalenedione (1.72 µg/ml); 2-methyl-1,4-naphthalenedione (9.12 µg/ml); 2-hydroxy-1,4-naphthalenedione (10.76 µg/ml); and 2-methoxy-1,4-naphthalenedione (12.50 µg/ml). Similar results were observed against Cx. p. pallens and Ae. togoi larvae with 1,4-naphthalenedione analogs. These results also showed that 1,4-naphthalenedione analogs were less toxic than the organophosphate pirimiphos-methyl. Nonetheless, naturally occurring C. chinensis-derived materials and 1,4-naphthalenedione analogs have potential for development as mosquito larvicidal agents.
本研究的目的是确定从紫荆心材中分离出的一种活性化合物及其结构相关类似物对埃及伊蚊、淡色库蚊和东乡伊蚊四龄幼虫的杀幼虫活性。利用各种色谱技术分离出紫荆的杀幼虫化合物，并鉴定为1,4-萘二酮的类似物。根据市购类似物对埃及伊蚊幼虫的半数致死浓度（LC50）值，毒性最强的类似物是2-溴-1,4-萘二酮（1.19 µg/ml）；其次是5-羟基-1,4-萘二酮（1.72 µg/ml）；2-甲基-1,4-萘二酮（9.12 µg/ml）；2-羟基-1,4-萘二酮（10.76 µg/ml）；以及2-甲氧基-1,4-萘二酮（12.50 µg/ml）。对淡色库蚊和东乡伊蚊幼虫使用1,4-萘二酮类似物时也观察到了类似结果。这些结果还表明，1,4-萘二酮类似物的毒性低于有机磷酸酯甲基嘧啶磷。尽管如此，天然存在的源自紫荆的材料和1,4-萘二酮类似物具有开发成为灭蚊幼虫剂的潜力。
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