National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
Carbohydr Polym. 2015 Jun 5;123:381-9. doi: 10.1016/j.carbpol.2015.01.047. Epub 2015 Feb 10.
A series of maleated hyaluronan (MaHA) are developed by modification with maleic anhydride. The degrees of substitution (DS) of MaHA vary between 7% and 75%. The DS of MaHA is both higher and wider than methacrylated HA derivatives (MeHA) reported in the literature. MaHA hydrogels are then prepared by photopolymerization and their dynamic mechanical and swelling properties of the hydrogels are investigated. The results showed that MaHA hydrogels with moderate DS (25%, 50% and 65%) have higher storage modulus and lower equilibrium swelling ratios than those with either low or high DS (7%, 15% and 75%). Theoretical analyses also suggest a similar pattern among hydrogels with different DS. The results confirm that the increased cross-linking density enhances the strength of hydrogels. Meanwhile, the hydrophilicity of introduced groups during modification and the degree of incomplete crosslinking reaction might have negative impact on the mechanical and swelling properties of MaHA hydrogels.
一系列马来化透明质酸（MaHA）通过马来酸酐修饰得到。MaHA 的取代度（DS）在 7%至 75%之间变化。MaHA 的 DS 比文献中报道的甲基丙烯酰化透明质酸衍生物（MeHA）更高且更宽。然后通过光聚合制备 MaHA 水凝胶，并研究其水凝胶的动态力学和溶胀性能。结果表明，具有中等 DS（25%、50%和 65%）的 MaHA 水凝胶的储能模量较高，平衡溶胀比低于具有低 DS（7%、15%）或高 DS（75%）的水凝胶。理论分析也表明不同 DS 的水凝胶之间存在类似的模式。结果证实，增加的交联密度增强了水凝胶的强度。同时，在修饰过程中引入基团的亲水性以及不完全交联反应的程度可能对 MaHA 水凝胶的机械性能和溶胀性能产生负面影响。
