颅骨骨髓和颅骨脑膜通道：重新定义中枢神经系统免疫监视格局

Skull bone marrow and skull meninges channels: redefining the landscape of central nervous system immune surveillance.

作者信息

Liu Liang, Zhang Xian, Chai Yan, Zhang Jianning, Deng Quanjun, Chen Xin

机构信息

Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, P.R. China.

Tianjin Neurological Institute, Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin, P.R. China.

出版信息

Cell Death Dis. 2025 Jan 29;16(1):53. doi: 10.1038/s41419-025-07336-2.

DOI:10.1038/s41419-025-07336-2

PMID:39875352

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11775313/

Abstract

The understanding of neuroimmune function has evolved from concepts of immune privilege and protection to a new stage of immune interaction. The discovery of skull meninges channels (SMCs) has opened new avenues for understanding central nervous system (CNS) immunity. Here, we characterize skull bone marrow and SMCs by detailing the anatomical structures adjacent to the skull, the differences between skull and peripheral bone marrow, mainstream animal processing methods, and the role of skull bone marrow in monitoring various CNS diseases. Additionally, we highlight several unresolved issues based on current research findings, aiming to guide future research directions.

摘要

对神经免疫功能的理解已从免疫豁免和保护的概念发展到免疫相互作用的新阶段。颅骨脑膜通道（SMC）的发现为理解中枢神经系统（CNS）免疫开辟了新途径。在这里，我们通过详细描述颅骨相邻的解剖结构、颅骨与外周骨髓的差异、主流动物处理方法以及颅骨骨髓在监测各种CNS疾病中的作用来表征颅骨骨髓和SMC。此外，我们根据当前的研究结果强调了几个未解决的问题，旨在指导未来的研究方向。