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利用酵母产生的银纳米颗粒对乳腺癌细胞系进行抗肿瘤活性研究。

Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast.

作者信息

Ortega Francisco G, Fernández-Baldo Martín A, Fernández Jorge G, Serrano María J, Sanz María I, Diaz-Mochón Juan J, Lorente José A, Raba Julio

机构信息

GENYO, Centre for Genomics and Oncological Research: Pfizer-University of Granada, Andalusian Regional Government, PTS Granada, Avenida de Ilustración, Granada, Spain.

INQUISAL, Departamento de Química, CONICET, Universidad Nacional de San Luis, San Luis, Argentina.

出版信息

Int J Nanomedicine. 2015 Mar 16;10:2021-31. doi: 10.2147/IJN.S75835. eCollection 2015.

DOI:10.2147/IJN.S75835
PMID:25844035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4368032/
Abstract

In the present article, we describe a study of antitumor activity in breast cell lines using silver nanoparticles (Ag NPs) synthesized by a microbiological method. These Ag NPs were tested for their antitumor activity against MCF7 and T47D cancer cells and MCF10-A normal breast cell line. We analyzed cell viability, apoptosis induction, and endocytosis activity of those cell lines and we observed that the effects of the biosynthesized Ag NPs were directly related with the endocytosis activity. Moreover, Ag NPs had higher inhibition efficacy in tumor lines than in normal lines of breast cells, which is due to the higher endocytic activity of tumor cells compared to normal cells. In this way, we demonstrate that biosynthesized Ag NPs can be an alternative for the treatment of tumors.

摘要

在本文中，我们描述了一项使用通过微生物方法合成的银纳米颗粒（Ag NPs）对乳腺癌细胞系进行抗肿瘤活性研究。这些Ag NPs针对MCF7和T47D癌细胞以及MCF10 - A正常乳腺细胞系进行了抗肿瘤活性测试。我们分析了这些细胞系的细胞活力、凋亡诱导和内吞活性，并且观察到生物合成的Ag NPs的作用与内吞活性直接相关。此外，Ag NPs在肿瘤细胞系中的抑制效果高于正常乳腺细胞系，这是由于肿瘤细胞相比于正常细胞具有更高的内吞活性。通过这种方式，我们证明生物合成的Ag NPs可以作为肿瘤治疗的一种替代方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebe0/4368032/093682551b10/ijn-10-2021Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebe0/4368032/7f6e5b57b5ef/ijn-10-2021Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebe0/4368032/75f3c969025d/ijn-10-2021Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebe0/4368032/bf6ecefe41a1/ijn-10-2021Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebe0/4368032/6140ad5734b7/ijn-10-2021Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebe0/4368032/ccb44b7049e7/ijn-10-2021Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebe0/4368032/5c6a41562c77/ijn-10-2021Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebe0/4368032/093682551b10/ijn-10-2021Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebe0/4368032/7f6e5b57b5ef/ijn-10-2021Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebe0/4368032/75f3c969025d/ijn-10-2021Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebe0/4368032/bf6ecefe41a1/ijn-10-2021Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebe0/4368032/6140ad5734b7/ijn-10-2021Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebe0/4368032/ccb44b7049e7/ijn-10-2021Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebe0/4368032/5c6a41562c77/ijn-10-2021Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebe0/4368032/093682551b10/ijn-10-2021Fig7.jpg

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