前列腺素F2α浓度在乳腺癌中的预后价值
Prognostic value of prostaglandin F2 alpha concentrations in breast carcinoma.
作者信息
van Dam P A, Vergote I B, Laekeman G M, Keersmaeckers G H, Uyttenbroeck F L, Herman A G
机构信息
Department of Gynaecology, St Camillus Hospital (Antwerp University), Belgium.
出版信息
J Clin Pathol. 1989 Oct;42(10):1046-8. doi: 10.1136/jcp.42.10.1046.
Prostaglandin F2 alpha (PGF2 alpha) concentrations were measured by radioimmunoassay in homogenised primary tumours from 57 patients with breast cancer. These patients were followed up from 60 to 78 months (median 63 months) after surgery and PGF2 alpha concentrations were related prospectively to metastatic spread and survival. The amounts of PGF2 alpha varied greatly in the different tumours (range 0-90 ng/mg protein), but no significant association was found between PGF2 alpha concentrations and disease free survival, time of relapse, site of recurrence, or overall survival. It therefore seems unlikely that measurement of PGF2 alpha in breast carcinoma is important in the prognosis of the disease.
采用放射免疫分析法测定了57例乳腺癌患者原发性肿瘤匀浆中的前列腺素F2α（PGF2α）浓度。这些患者在手术后随访了60至78个月（中位时间63个月），PGF2α浓度与转移扩散和生存率进行了前瞻性关联研究。不同肿瘤中PGF2α的含量差异很大（范围为0 - 90 ng/mg蛋白质），但未发现PGF2α浓度与无病生存期、复发时间、复发部位或总生存期之间存在显著关联。因此，在乳腺癌中测量PGF2α对该疾病的预后似乎不太重要。
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