一个细胞，多种角色：间质干细胞在肿瘤微环境中对肿瘤发展的贡献。
One cell, multiple roles: contribution of mesenchymal stem cells to tumor development in tumor microenvironment.
机构信息
Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, the Second Military Medicial University, 225 Changhai Road, Shanghai 200438, China.
出版信息
Cell Biosci. 2013 Jan 21;3(1):5. doi: 10.1186/2045-3701-3-5.
Abstract
The discovery of tissue reparative and immunosuppressive abilities of mesenchymal stem cells (MSCs) has drawn more attention to tumor microenvironment and its role in providing the soil for the tumor cell growth. MSCs are recruited to tumor which is referred as the never healing wound and altered by the inflammation environment, thereby helping to construct the tumor microenvironment. The environment orchestrated by MSCs and other factors can be associated with angiogenesis, immunosuppression, inhibition of apoptosis, epithelial-mesenchymal transition (EMT), survival of cancer stem cells, which all contribute to tumor growth and progression. In this review, we will discuss how MSCs are recruited to the tumor microenvironment and what effects they have on tumor progression.
摘要
间充质干细胞（MSCs）具有组织修复和免疫抑制能力，这一发现引起了人们对肿瘤微环境及其为肿瘤细胞生长提供土壤作用的更多关注。MSCs 被招募到肿瘤部位，即所谓的永不愈合的伤口，并被炎症环境改变，从而有助于构建肿瘤微环境。MSCs 和其他因素协调的环境可与血管生成、免疫抑制、细胞凋亡抑制、上皮-间充质转化（EMT）、癌症干细胞存活相关，所有这些都有助于肿瘤的生长和进展。在这篇综述中，我们将讨论 MSCs 如何被招募到肿瘤微环境中，以及它们对肿瘤进展的影响。
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