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The molecular epidemiology of Treponema pallidum subspecies pallidum.梅毒螺旋体苍白亚种的分子流行病学
Sex Health. 2015 Apr;12(2):141-7. doi: 10.1071/SH14197.
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Fine analysis of genetic diversity of the tpr gene family among treponemal species, subspecies and strains.对密螺旋体属种、亚种和菌株中 tpr 基因家族的遗传多样性进行精细分析。
PLoS Negl Trop Dis. 2013 May 16;7(5):e2222. doi: 10.1371/journal.pntd.0002222. Print 2013.
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Treponema pallidum Subspecies Intrapatient Homogeneity at Various Body Locations in Men with Infectious Syphilis.梅毒密螺旋体亚种 感染性梅毒男性不同身体部位的患者内同质性
Microbiol Spectr. 2022 Aug 31;10(4):e0248221. doi: 10.1128/spectrum.02482-21. Epub 2022 Jun 23.
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The pan-genome of Treponema pallidum reveals differences in genome plasticity between subspecies related to venereal and non-venereal syphilis.苍白密螺旋体的泛基因组揭示了与性病和非性病梅毒相关亚种之间在基因组可塑性方面的差异。
BMC Genomics. 2020 Jan 10;21(1):33. doi: 10.1186/s12864-019-6430-6.
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Genotyping of Treponema pallidum in Cuba (2018-2019): Increased Circulation of Recombinant Genotype and No New Treponema pallidum Subspecies endemicum Infection Among Syphilis Patients.古巴梅毒螺旋体基因分型（2018 - 2019年）：梅毒患者中重组基因型传播增加且无新的地方性梅毒亚种感染
Sex Transm Dis. 2020 Oct;47(10):e39-e41. doi: 10.1097/OLQ.0000000000001217.
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Syphilis-causing strains belong to separate SS14-like or Nichols-like groups as defined by multilocus analysis of 19 Treponema pallidum strains.梅毒致病菌株如通过对19株梅毒螺旋体菌株进行多位点分析所定义的那样，属于不同的SS14样或Nichols样菌群。
Int J Med Microbiol. 2014 Jul;304(5-6):645-53. doi: 10.1016/j.ijmm.2014.04.007. Epub 2014 Apr 26.
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Enhanced Molecular Typing of Treponema pallidum subspecies pallidum Strains From 4 Italian Hospitals Shows Geographical Differences in Strain Type Heterogeneity, Widespread Resistance to Macrolides, and Lack of Mutations Associated With Doxycycline Resistance.增强梅毒螺旋体亚种苍白亚种菌株的分子分型显示来自 4 家意大利医院的菌株在菌株类型异质性、大环内酯类广泛耐药以及缺乏与强力霉素耐药相关的突变方面存在地理差异。
Sex Transm Dis. 2018 Apr;45(4):237-242. doi: 10.1097/OLQ.0000000000000741.
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Estimation of Full-Length TprK Diversity in Treponema pallidum subsp. .估计苍白密螺旋体亚种中全长 TprK 的多样性。
mBio. 2020 Oct 27;11(5):e02726-20. doi: 10.1128/mBio.02726-20.
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Selective Whole-Genome Amplification as a Tool to Enrich Specimens with Low Treponema pallidum Genomic DNA Copies for Whole-Genome Sequencing.选择全基因组扩增作为一种工具，用于富集基因组 DNA 拷贝量低的梅毒螺旋体标本，以便进行全基因组测序。
mSphere. 2022 Jun 29;7(3):e0000922. doi: 10.1128/msphere.00009-22. Epub 2022 May 2.
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subsp. with an Artificially Impaired TprK Antigenic Variation System is Attenuated in the Rabbit Model of Syphilis.在梅毒兔模型中，具有人工受损TprK抗原变异系统的亚种减毒。
bioRxiv. 2023 Feb 23:2023.01.18.524629. doi: 10.1101/2023.01.18.524629.
引用本文的文献
1
Molecular characterization of 'Candidatus Borrelia tachyglossi' (family Spirochaetaceae) in echidna ticks, Bothriocroton concolor.针鼹蜱（Bothriocroton concolor）中“嗜速假疏螺旋体（Candidatus Borrelia tachyglossi）”（螺旋体科）的分子特征分析
Int J Syst Evol Microbiol. 2017 Apr;67(4):1075-1080. doi: 10.1099/ijsem.0.001929.
本文引用的文献
1
Molecular typing of Treponema pallidum in the Czech Republic during 2011 to 2013: increased prevalence of identified genotypes and of isolates with macrolide resistance.2011年至2013年捷克共和国梅毒螺旋体的分子分型：已鉴定基因型及大环内酯类耐药菌株的患病率增加。
J Clin Microbiol. 2014 Oct;52(10):3693-700. doi: 10.1128/JCM.01292-14. Epub 2014 Aug 6.
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Azithromycin-resistant syphilis-causing strains in Sydney, Australia: prevalence and risk factors.澳大利亚悉尼的阿奇霉素耐药梅毒致病菌株：患病率及风险因素
J Clin Microbiol. 2014 Aug;52(8):2776-81. doi: 10.1128/JCM.00301-14. Epub 2014 May 21.
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Syphilis-causing strains belong to separate SS14-like or Nichols-like groups as defined by multilocus analysis of 19 Treponema pallidum strains.梅毒致病菌株如通过对19株梅毒螺旋体菌株进行多位点分析所定义的那样，属于不同的SS14样或Nichols样菌群。
Int J Med Microbiol. 2014 Jul;304(5-6):645-53. doi: 10.1016/j.ijmm.2014.04.007. Epub 2014 Apr 26.
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Complete Genome Sequence of the Treponema pallidum subsp. pallidum Sea81-4 Strain.梅毒螺旋体苍白亚种Sea81-4菌株的全基因组序列
Genome Announc. 2014 Apr 17;2(2):e00333-14. doi: 10.1128/genomeA.00333-14.
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Multicentre surveillance of prevalence of the 23S rRNA A2058G and A2059G point mutations and molecular subtypes of Treponema pallidum in Taiwan, 2009-2013.2009-2013 年台湾地区 23S rRNA A2058G 和 A2059G 点突变及梅毒螺旋体分子亚型的多中心监测。
Clin Microbiol Infect. 2014 Aug;20(8):802-7. doi: 10.1111/1469-0691.12529. Epub 2014 Feb 13.
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Resequencing of Treponema pallidum ssp. pallidum strains Nichols and SS14: correction of sequencing errors resulted in increased separation of syphilis treponeme subclusters.梅毒密螺旋体亚种苍白密螺旋体 Nichols 株和 SS14 株的重测序：测序错误的校正导致梅毒密螺旋体亚群的分离增加。
PLoS One. 2013 Sep 10;8(9):e74319. doi: 10.1371/journal.pone.0074319. eCollection 2013.
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Comparison of CDC and sequence-based molecular typing of syphilis treponemes: tpr and arp loci are variable in multiple samples from the same patient.梅毒螺旋体的 CDC 与基于序列的分子分型比较：来自同一患者的多个样本中 tpr 和 arp 基因座存在变异性。
BMC Microbiol. 2013 Jul 30;13:178. doi: 10.1186/1471-2180-13-178.
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Fine analysis of genetic diversity of the tpr gene family among treponemal species, subspecies and strains.对密螺旋体属种、亚种和菌株中 tpr 基因家族的遗传多样性进行精细分析。
PLoS Negl Trop Dis. 2013 May 16;7(5):e2222. doi: 10.1371/journal.pntd.0002222. Print 2013.
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Complete genome sequence of Treponema pallidum strain DAL-1.梅毒螺旋体菌株DAL-1的全基因组序列
Stand Genomic Sci. 2012 Oct 10;7(1):12-21. doi: 10.4056/sigs.2615838. Epub 2012 Sep 24.
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Whole genome sequence of Treponema pallidum ssp. pallidum, strain Mexico A, suggests recombination between yaws and syphilis strains.苍白密螺旋体亚种苍白密螺旋体墨西哥 A 株的全基因组序列提示雅司病和梅毒菌株之间存在重组。
PLoS Negl Trop Dis. 2012;6(9):e1832. doi: 10.1371/journal.pntd.0001832. Epub 2012 Sep 20.
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