Ma Daphne Y, Giacani Lorenzo, Centurión-Lara Arturo
University of Washington, Department of Global Health, 325 9th Avenue, Seattle, WA, 98104, USA.
Universidad Peruana Cayetano Heredia, Facultad de Salud Pública, Avenida Honorio Delgado 430, San Martín de Porres 15102, Lima, Perú.
Sex Health. 2015 Apr;12(2):141-7. doi: 10.1071/SH14197.
Pathogens adapt and evolve in response to pressures exerted by host environments, leading to generation of genetically diverse variants. Treponema pallidum subspecies pallidum displays a substantial amount of interstrain diversity. These variants have been identified in various parts of the world, indicating transmission linkage between geographical regions. Genotyping is based on molecular characterisation of various loci in the syphilis treponeme genome, but still require further development and continued research, as new bacterial types are continually being detected. The goal for studying the molecular epidemiology of Treponema pallidum variants is the global monitoring of the transmission of genetically distinct organisms with different drug sensitivities and, potentially, different virulence proprieties.
病原体为应对宿主环境施加的压力而适应和进化，导致产生基因多样化的变体。梅毒螺旋体苍白亚种表现出大量的菌株间差异。这些变体已在世界不同地区被发现，表明地理区域之间存在传播联系。基因分型基于梅毒螺旋体基因组中各个位点的分子特征，但仍需要进一步发展和持续研究，因为新的细菌类型不断被检测到。研究梅毒螺旋体变体分子流行病学的目标是对具有不同药物敏感性以及可能具有不同毒力特性的基因不同的生物体的传播进行全球监测。
