梅毒螺旋体苍白亚种Sea81-4菌株的全基因组序列
Complete Genome Sequence of the Treponema pallidum subsp. pallidum Sea81-4 Strain.
作者信息
Giacani Lorenzo, Iverson-Cabral Stefanie L, King Jordon C K, Molini Barbara J, Lukehart Sheila A, Centurion-Lara Arturo
机构信息
Department of Medicine, University of Washington, Seattle, Washington, USA.
出版信息
Genome Announc. 2014 Apr 17;2(2):e00333-14. doi: 10.1128/genomeA.00333-14.
Abstract
Using the rabbit model of syphilis, the Sea81-4 strain of Treponema pallidum subsp. pallidum has been found to be more likely than other strains to invade the central nervous system (CNS). To identify possible explanations for this important phenotype at the genomic level, we sequenced the Sea81-4 strain genome.
摘要
利用梅毒兔模型，已发现梅毒螺旋体苍白亚种的Sea81-4菌株比其他菌株更易侵入中枢神经系统（CNS）。为了在基因组水平上找出导致这一重要表型的可能原因，我们对Sea81-4菌株的基因组进行了测序。
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本文引用的文献
1
Comparative investigation of the genomic regions involved in antigenic variation of the TprK antigen among treponemal species, subspecies, and strains.梅毒螺旋体属种、亚种和株间 TprK 抗原抗原变异相关基因组区域的比较研究。
J Bacteriol. 2012 Aug;194(16):4208-25. doi: 10.1128/JB.00863-12. Epub 2012 Jun 1.
2
Complete genome sequence and annotation of the Treponema pallidum subsp. pallidum Chicago strain.苍白密螺旋体亚种芝加哥株的全基因组序列和注释。
J Bacteriol. 2010 May;192(10):2645-6. doi: 10.1128/JB.00159-10. Epub 2010 Mar 26.
3
Length of guanosine homopolymeric repeats modulates promoter activity of subfamily II tpr genes of Treponema pallidum ssp. pallidum.梅毒螺旋体苍白亚种II型tpr基因亚家族的鸟苷同聚体重复序列长度调节启动子活性。
FEMS Immunol Med Microbiol. 2007 Nov;51(2):289-301. doi: 10.1111/j.1574-695X.2007.00303.x. Epub 2007 Aug 7.
4
Treponema pallidum strain-specific differences in neuroinvasion and clinical phenotype in a rabbit model.梅毒螺旋体在兔模型中神经侵袭和临床表型的菌株特异性差异。
J Infect Dis. 2005 Jan 1;191(1):75-80. doi: 10.1086/426510. Epub 2004 Nov 30.
5
The Oslo study of untreated syphilis; an epidemiologic investigation of the natural course of the syphilitic infection based upon a re-study of the Boeck-Bruusgaard material.奥斯陆未经治疗梅毒的研究；基于对伯克-布鲁斯加德资料的重新研究对梅毒感染自然病程的流行病学调查。
Acta Derm Venereol Suppl (Stockh). 1955;35(Suppl 34):3-368; Annex I-LVI. doi: 10.2340/00015555343368.
6
Update on syphilis: resurgence of an old problem.梅毒最新情况：一个老问题的再度出现。
JAMA. 2003 Sep 17;290(11):1510-4. doi: 10.1001/jama.290.11.1510.
7
Global prevalence and incidence estimates of selected curable STDs.特定可治愈性传播感染的全球患病率和发病率估计。
Sex Transm Infect. 1998 Jun;74 Suppl 1:S12-6.
8
Neurosyphilis.神经梅毒
Arch Neurol. 1985 Jun;42(6):606-13. doi: 10.1001/archneur.1985.04060060112021.
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