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梅毒螺旋体苍白亚种Sea81-4菌株的全基因组序列

Complete Genome Sequence of the Treponema pallidum subsp. pallidum Sea81-4 Strain.

作者信息

Giacani Lorenzo, Iverson-Cabral Stefanie L, King Jordon C K, Molini Barbara J, Lukehart Sheila A, Centurion-Lara Arturo

机构信息

Department of Medicine, University of Washington, Seattle, Washington, USA.

出版信息

Genome Announc. 2014 Apr 17;2(2):e00333-14. doi: 10.1128/genomeA.00333-14.

DOI:10.1128/genomeA.00333-14
PMID:24744342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3990758/
Abstract

Using the rabbit model of syphilis, the Sea81-4 strain of Treponema pallidum subsp. pallidum has been found to be more likely than other strains to invade the central nervous system (CNS). To identify possible explanations for this important phenotype at the genomic level, we sequenced the Sea81-4 strain genome.

摘要

利用梅毒兔模型，已发现梅毒螺旋体苍白亚种的Sea81-4菌株比其他菌株更易侵入中枢神经系统（CNS）。为了在基因组水平上找出导致这一重要表型的可能原因，我们对Sea81-4菌株的基因组进行了测序。

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