Li Weizhong, Cowley Andrew, Uludag Mahmut, Gur Tamer, McWilliam Hamish, Squizzato Silvano, Park Young Mi, Buso Nicola, Lopez Rodrigo
European Bioinformatics Institute, EMBL Outstation, Wellcome Trust Genome Campus, Hinxton, CB10 1SD, Cambridge, UK.
European Bioinformatics Institute, EMBL Outstation, Wellcome Trust Genome Campus, Hinxton, CB10 1SD, Cambridge, UK
Nucleic Acids Res. 2015 Jul 1;43(W1):W580-4. doi: 10.1093/nar/gkv279. Epub 2015 Apr 6.
Since 2009 the EMBL-EBI Job Dispatcher framework has provided free access to a range of mainstream sequence analysis applications. These include sequence similarity search services (https://www.ebi.ac.uk/Tools/sss/) such as BLAST, FASTA and PSI-Search, multiple sequence alignment tools (https://www.ebi.ac.uk/Tools/msa/) such as Clustal Omega, MAFFT and T-Coffee, and other sequence analysis tools (https://www.ebi.ac.uk/Tools/pfa/) such as InterProScan. Through these services users can search mainstream sequence databases such as ENA, UniProt and Ensembl Genomes, utilising a uniform web interface or systematically through Web Services interfaces (https://www.ebi.ac.uk/Tools/webservices/) using common programming languages, and obtain enriched results with novel visualisations. Integration with EBI Search (https://www.ebi.ac.uk/ebisearch/) and the dbfetch retrieval service (https://www.ebi.ac.uk/Tools/dbfetch/) further expands the usefulness of the framework. New tools and updates such as NCBI BLAST+, InterProScan 5 and PfamScan, new categories such as RNA analysis tools (https://www.ebi.ac.uk/Tools/rna/), new databases such as ENA non-coding, WormBase ParaSite, Pfam and Rfam, and new workflow methods, together with the retirement of depreciated services, ensure that the framework remains relevant to today's biological community.
自2009年以来，欧洲生物信息学研究所（EMBL-EBI）作业调度框架提供了对一系列主流序列分析应用程序的免费访问。这些应用包括序列相似性搜索服务（https://www.ebi.ac.uk/Tools/sss/），如BLAST、FASTA和PSI-Search；多序列比对工具（https://www.ebi.ac.uk/Tools/msa/），如Clustal Omega、MAFFT和T-Coffee；以及其他序列分析工具（https://www.ebi.ac.uk/Tools/pfa/），如InterProScan。通过这些服务，用户可以使用统一的网页界面搜索主流序列数据库，如ENA、UniProt和Ensembl基因组数据库，也可以通过网络服务接口（https://www.ebi.ac.uk/Tools/webservices/），使用常用编程语言进行系统搜索，并获得带有新颖可视化效果的丰富结果。与EBI Search（https://www.ebi.ac.uk/ebisearch/）和dbfetch检索服务（https://www.ebi.ac.uk/Tools/dbfetch/）的集成进一步扩展了该框架的实用性。新工具和更新，如NCBI BLAST+、InterProScan 5和PfamScan，新类别，如RNA分析工具（https://www.ebi.ac.uk/Tools/rna/），新数据库，如ENA非编码数据库、线虫基因组寄生虫数据库、Pfam和Rfam，以及新的工作流程方法，再加上淘汰过时的服务，确保该框架与当今的生物学界保持相关性。
