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本文引用的文献

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Worldwide dissemination of the NDM-type carbapenemases in Gram-negative bacteria.NDM型碳青霉烯酶在革兰氏阴性菌中的全球传播。
Biomed Res Int. 2014;2014:249856. doi: 10.1155/2014/249856. Epub 2014 Mar 26.
2
Complete sequences of two plasmids in a blaNDM-1-positive Klebsiella oxytoca isolate from Taiwan.来自台湾的一株产 blaNDM-1 型金属酶的阴沟肠杆菌中两种质粒的完整序列。
Antimicrob Agents Chemother. 2013 Aug;57(8):4072-6. doi: 10.1128/AAC.02266-12. Epub 2013 Jun 10.
3
Outbreak of carbapenem-resistant enterobacteriaceae containing blaNDM-1, Ontario, Canada.加拿大安大略省爆发携带 blaNDM-1 的碳青霉烯类耐药肠杆菌科细菌。
Clin Infect Dis. 2012 Dec;55(11):e109-17. doi: 10.1093/cid/cis737. Epub 2012 Sep 20.
4
Evolution of IncA/C blaCMY-₂-carrying plasmids by acquisition of the blaNDM-₁ carbapenemase gene.携带 IncA/C blaCMY-₂ 质粒的进化是通过获得 blaNDM-₁ 碳青霉烯酶基因实现的。
Antimicrob Agents Chemother. 2012 Feb;56(2):783-6. doi: 10.1128/AAC.05116-11. Epub 2011 Nov 28.
5
Pelvic abscess caused by New Delhi metallo-β-lactamase-1-producing Klebsiella oxytoca in Taiwan in a patient who underwent renal transplantation in China.台湾地区一名在中国接受肾移植的患者，因产新德里金属β-内酰胺酶-1的产酸克雷伯菌导致盆腔脓肿。
Diagn Microbiol Infect Dis. 2011 Dec;71(4):474-5. doi: 10.1016/j.diagmicrobio.2011.09.004.
6
New Delhi metallo-beta-lactamase, Ontario, Canada.新德里金属β-内酰胺酶，加拿大安大略省
Emerg Infect Dis. 2011 Feb;17(2):306-7. doi: 10.3201/eid1702.101561.
7
New Delhi metallo-β-lactamase in Klebsiella pneumoniae and Escherichia coli, Canada.加拿大肺炎克雷伯菌和大肠埃希菌中的新德里金属β-内酰胺酶。
Emerg Infect Dis. 2011 Jan;17(1):103-6. doi: 10.3201/eid1701.101358.
8
Detection of NDM-1-producing Klebsiella pneumoniae in Kenya.肯尼亚产 NDM-1 的肺炎克雷伯菌的检测。
Antimicrob Agents Chemother. 2011 Feb;55(2):934-6. doi: 10.1128/AAC.01247-10. Epub 2010 Nov 29.
9
rmtD2, a new allele of a 16S rRNA methylase gene, has been present in Enterobacteriaceae isolates from Argentina for more than a decade.rmtD2 是 16S rRNA 甲基酶基因的一个新等位基因，在来自阿根廷的肠杆菌科分离株中存在已超过十年。
Antimicrob Agents Chemother. 2011 Feb;55(2):904-9. doi: 10.1128/AAC.00962-10. Epub 2010 Nov 15.
10
Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India.印度肺炎克雷伯菌 14 型携带新型金属β-内酰胺酶基因 bla(NDM-1)和新型红霉素酯酶基因的独特遗传结构特征。
Antimicrob Agents Chemother. 2009 Dec;53(12):5046-54. doi: 10.1128/AAC.00774-09. Epub 2009 Sep 21.

对同一患者分离出的多种产NDM-1肠杆菌科细菌的特性分析。

Characterization of multiple NDM-1-producing Enterobacteriaceae isolates from the same patient.

作者信息

Tijet Nathalie, Richardson David, MacMullin Gregory, Patel Samir N, Melano Roberto G

机构信息

Public Health Ontario Laboratories, Toronto, Ontario, Canada.

Division of Infectious Diseases, McMaster University, Hamilton, Ontario, Canada Department of Laboratory Medicine, McMaster University, Hamilton, Ontario, Canada Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

出版信息

Antimicrob Agents Chemother. 2015;59(6):3648-51. doi: 10.1128/AAC.04862-14. Epub 2015 Apr 6.

DOI:10.1128/AAC.04862-14
PMID:25845877
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4432124/
Abstract

A male patient was admitted to a community hospital in Ontario, Canada, with an infected sacral ulcer after returning from India, where he was hospitalized. Carbapenem-resistant Escherichia coli (isolated from blood cultures), Enterobacter cloacae, and Providencia stuartii (from urine samples), all positive for bla(NDM-1), were recovered. Comparative NDM-1 plasmid analysis suggests both lateral plasmid transfer and independent acquisition of the bla(NDM-1) gene in these clinical isolates.

摘要

一名男性患者从印度住院归来后，因骶骨溃疡感染入住加拿大安大略省的一家社区医院。从其血液培养物中分离出的耐碳青霉烯类大肠杆菌、阴沟肠杆菌以及从尿液样本中分离出的斯氏普罗威登斯菌，均检测出bla(NDM-1)呈阳性。NDM-1质粒比较分析表明，在这些临床分离株中存在质粒横向转移以及bla(NDM-1)基因的独立获得情况。