Thalasselis A, Taie H F
Instituto de la Vision, Mar del Plata. Pcia. de Buenos Aires, Argentina.
J Am Optom Assoc. 1989 Oct;60(10):754-8.
The etiology of keratoconus is still unclear. This study presents a new clinical sign, Thalasselis' syndrome, defined as: an association between keratoconus, magnesium deficiency, type-A behavior and allergy. Also, it introduces the hypothesis that magnesium deficiency could affect pathologically the osmotic mechanism of the cornea, specifically the Na-K and/or Ca-ATPase pumps; the collagen structure by alteration of the adenylate cyclase activity; and other mechanisms as well. Furthermore, we propose the Thalasselis' syndrome is compatible with previous theories on keratoconus. In addition to the other therapeutic measures, such as contact lenses and keratoplasty, this study suggests a clinical, nutritional, psychological, and immunological treatment for keratoconic patients.
圆锥角膜的病因仍不清楚。本研究提出了一种新的临床体征，即塔拉萨利斯综合征，定义为：圆锥角膜、镁缺乏、A型行为和过敏之间的关联。此外，还提出了一种假说，即镁缺乏可能在病理上影响角膜的渗透机制，特别是钠钾和/或钙ATP酶泵；通过改变腺苷酸环化酶活性影响胶原蛋白结构；以及其他机制。此外，我们认为塔拉萨利斯综合征与先前关于圆锥角膜的理论相符。除了隐形眼镜和角膜移植等其他治疗措施外，本研究还为圆锥角膜患者提出了一种临床、营养、心理和免疫治疗方法。
