Thalasselis A, Taie H F, Etchepareborda J, Selim A
Vision Institute, Mar del Plata, Argentina.
Am J Optom Physiol Opt. 1988 Jun;65(6):499-505. doi: 10.1097/00006324-198806000-00010.
The etiology of keratoconus is still unknown. This project was designed to study, in a group of keratoconic patients and a control group, the following: clinical, endocrinological, immunological, psychological, and ophthalmological factors. We found mean serum magnesium deficiency and type A behavior to be significantly more common in keratoconic patients than in a control group of patients. In addition changes in gluco-mineral corticoids, changes in glucose metabolism, edema of allergic origin, and genetic factors may collaborate in the development of keratoconus. All these factors could affect the osmotic mechanism of the cornea: Na-K and/or Ca ATPase, the collagen structure by alteration of the adenylate cyclase activity, and other mechanisms. This study suggests an association between keratoconus, magnesium depletion, and type A behavior, which together constitute a new clinical syndrome and confirm an association between keratoconus and atopy.
圆锥角膜的病因仍然不明。本项目旨在对一组圆锥角膜患者和一个对照组进行以下研究：临床、内分泌、免疫、心理和眼科因素。我们发现，圆锥角膜患者血清镁缺乏和A型行为的发生率显著高于对照组患者。此外，糖皮质激素变化、糖代谢变化、过敏性水肿和遗传因素可能共同作用于圆锥角膜的发展。所有这些因素可能影响角膜的渗透机制：钠钾和/或钙ATP酶、通过改变腺苷酸环化酶活性影响胶原结构以及其他机制。本研究表明圆锥角膜、镁缺乏和A型行为之间存在关联，它们共同构成一种新的临床综合征，并证实圆锥角膜与特应性之间存在关联。
