Benjamin Philip, Viessmann Olivia, MacKinnon Andrew D, Jezzard Peter, Markus Hugh S
Neurosciences Research Centre, St George's University of London, London, UK.
Functional MRI of the Brain (FMRIB) Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Int J Stroke. 2015 Jul;10(5):659-64. doi: 10.1111/ijs.12490. Epub 2015 Apr 6.
Cerebral small vessel disease (SVD) is a major cause of stroke and cognitive decline. Magnetic resonance imaging (MRI) currently plays a central role in diagnosis, and advanced MRI techniques are widely used in research but are limited by spatial resolution. Human 7 Tesla (7T) MRI has recently become available offering the ability to image at higher spatial resolution. This may provide additional insights into both the vascular pathology itself as well as parenchymal markers which could only previously be examined post mortem. In this review we cover the advantages and limitations of 7T MRI, review studies in SVD performed to date, and discuss potential future insights into SVD which 7T MRI may provide.
脑小血管病(SVD)是中风和认知衰退的主要原因。磁共振成像(MRI)目前在诊断中起着核心作用,先进的MRI技术在研究中被广泛使用,但受空间分辨率限制。人类7特斯拉(7T)MRI最近已可用于提供更高空间分辨率的成像。这可能为血管病理学本身以及以前只能在尸检后检查的实质标志物提供更多见解。在本综述中,我们阐述了7T MRI的优点和局限性,回顾了迄今为止在SVD中进行的研究,并讨论了7T MRI可能提供的对SVD未来潜在的见解。