Szumowski Suzannah C, Troemel Emily R
Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States.
Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States.
Curr Opin Microbiol. 2015 Aug;26:10-6. doi: 10.1016/j.mib.2015.03.006. Epub 2015 Apr 4.
Microsporidia comprise one of the largest groups of obligate intracellular pathogens and can infect virtually all animals, but host response to these fungal-related microbes has been poorly understood. Several new studies of the host transcriptional response to microsporidia infection have found infection-induced regulation of genes involved in innate immunity, ubiquitylation, metabolism, and hormonal signaling. In addition, microsporidia have recently been shown to exploit host recycling endocytosis for exit from intestinal cells, and to interact with host degradation pathways. Microsporidia infection has also been shown to profoundly affect behavior in insect hosts. Altogether, these and other recent findings are providing much-needed insight into the underlying mechanisms of microsporidia interaction with host animals.
微孢子虫是专性细胞内病原体中最大的类群之一，几乎可感染所有动物，但宿主对这些真菌相关微生物的反应却鲜为人知。几项关于宿主对微孢子虫感染的转录反应的新研究发现，感染会诱导参与先天免疫、泛素化、代谢和激素信号传导的基因发生调控。此外，最近研究表明微孢子虫利用宿主循环内吞作用从肠道细胞中逸出，并与宿主降解途径相互作用。微孢子虫感染还被证明会深刻影响昆虫宿主的行为。总之，这些以及其他最近的发现为深入了解微孢子虫与宿主动物相互作用的潜在机制提供了急需的见解。
