Roly Zahida Yesmin, Hakim Md Abdul, Zahan Asm Shahriar, Hossain M Monzur, Reza Md Abu
Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi-6205, Bangladesh.
Department of Botany, University of Rajshahi, Rajshahi-6205, Bangladesh.
Bioinformation. 2015 Feb 28;11(2):107-14. doi: 10.6026/97320630011107. eCollection 2015.
At present there is no well structured database available for the venomous snakes and venom composition of snakes in the world although venom has immense importance in biomedical research. Searching for a specific venom component from NCBI, PDB or public databases is troublesome, because they contain huge amount of data entries. Therefore, we created a database named "ISOB" which is a web accessible unique secondary database that represents the first online available bioinformatics resource showing venom composition of snakes. This database provides a comprehensive overview of seventy-eight indigenous snake species covering description of snakes supplemented with structural information of the relevant individual available venom proteins. We strongly believe that this database will contribute significantly in the field of bioinformatics, environmental research, proteomics, drug development and rationale drug designing.
The database is freely available at http://www.snakebd.com/.
目前，尽管毒液在生物医学研究中具有极其重要的意义，但世界上尚无结构完善的毒蛇及蛇毒成分数据库。从美国国立生物技术信息中心（NCBI）、蛋白质数据库（PDB）或公共数据库中搜索特定的毒液成分很麻烦，因为它们包含大量的数据条目。因此，我们创建了一个名为“ISOB”的数据库，它是一个可通过网络访问的独特二级数据库，是首个在线提供的展示蛇毒成分的生物信息学资源。该数据库全面概述了78种本土蛇类物种，涵盖蛇类描述，并补充了相关单个可用毒液蛋白的结构信息。我们坚信，这个数据库将在生物信息学、环境研究、蛋白质组学、药物开发和合理药物设计领域做出重大贡献。
