Xie Bing, Huang Yu, Baumann Kate, Fry Bryan Grieg, Shi Qiong
Venomics Research Group, BGI-Shenzhen, Shenzhen 518083, China.
Shenzhen Key Lab of Marine Genomics, Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic Animals, BGI, Shenzhen 518083, China.
Mar Drugs. 2017 Mar 30;15(4):103. doi: 10.3390/md15040103.
The potential of marine natural products to become new drugs is vast; however, research is still in its infancy. The chemical and biological diversity of marine toxins is immeasurable and as such an extraordinary resource for the discovery of new drugs. With the rapid development of next-generation sequencing (NGS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS), it has been much easier and faster to identify more toxins and predict their functions with bioinformatics pipelines, which pave the way for novel drug developments. Here we provide an overview of related bioinformatics pipelines that have been supported by a combination of transcriptomics and proteomics for identification and function prediction of novel marine toxins.
海洋天然产物成为新药的潜力巨大;然而,相关研究仍处于起步阶段。海洋毒素的化学和生物多样性不可估量,是发现新药的非凡资源。随着下一代测序(NGS)和液相色谱 - 串联质谱(LC-MS/MS)的快速发展,利用生物信息学管道识别更多毒素并预测其功能变得更加容易和快捷,这为新型药物开发铺平了道路。在此,我们概述了相关生物信息学管道,这些管道得到了转录组学和蛋白质组学相结合的支持,用于新型海洋毒素的识别和功能预测。