Samut Gülbüz, Dinçer Fitnat, Özdemir Oya
a Department of Physical Medicine and Rehabilitation , Hacettepe University Faculty of Medicine , Ankara , Turkey.
Mod Rheumatol. 2015;25(6):919-24. doi: 10.3109/14397595.2015.1038425. Epub 2015 May 27.
The aim of this study is to investigate the effects of isokinetic and aerobic exercise training programs on serum pro-inflammatory cytokine levels, pain, and functional activity in patients with knee osteoarthritis (OA).
Forty-two postmenopausal women and men with knee OA according to American College of Rheumatology diagnostic criteria were included. Patients were randomized into isokinetic and aerobic exercises and control groups. In intervention groups, patients were included in predetermined exercise programs 3 times per week for 6 weeks. Severity of pain, functional activity status, muscle strength, functional capacity, and serum cytokine levels were evaluated at baseline and at the 6th week.
At the end of 6th week, there was no statistically significant decrease in serum pro-inflammatory cytokine levels in both the exercise groups, although C-reactive protein levels exhibited a strong trend toward significance. We found a significant decrease in visual analog scale and Western Ontario McMaster Osteoarthritis Index scores, and significant increase in functional capacity and muscle strength in both the exercise groups compared with those in the control group.
本研究旨在探讨等速运动和有氧运动训练方案对膝骨关节炎（OA）患者血清促炎细胞因子水平、疼痛及功能活动的影响。
纳入42例符合美国风湿病学会诊断标准的绝经后膝OA男女患者。患者被随机分为等速运动组、有氧运动组和对照组。在干预组中，患者每周进行3次预定的运动方案，共6周。在基线和第6周时评估疼痛严重程度、功能活动状态、肌肉力量、功能能力和血清细胞因子水平。
在第6周结束时，尽管C反应蛋白水平有显著下降的强烈趋势，但两个运动组的血清促炎细胞因子水平均无统计学意义上的显著下降。与对照组相比，我们发现两个运动组的视觉模拟评分和西安大略和麦克马斯特大学骨关节炎指数评分均显著降低，功能能力和肌肉力量均显著增加。
