Huang Man, Wang Dejun, Xu Zhijun, Xu Yongshan, Xu Xiaoping, Ma Yuefeng, Xia Zheng
Department of General Intensive Care Unit, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Am J Alzheimers Dis Other Demen. 2015 Sep;30(6):541-6. doi: 10.1177/1533317515577128.
Large-scale genome-wide association studies have identified TREM2 variants to be significantly associated with Alzheimer's disease (AD) in caucasian population. The goal of this systematic study and meta-analysis was to assess the association between Triggering receptor expressed on myeloid cells 2 (TREM2) variants and AD in East Asian population.
In this study, literatures were searched in PubMed, MEDLINE, EMBASE, and the Cochrane library to screen citations from January 1990 to June 2014. Data analysis was done by using the Stata 12 software.
Twelve studies were considered for analysis. A total of 13 535 patients with AD and 22 976 healthy controls were studied. The results showed that rs75932628 variant was significantly associated with AD in caucasian population (P < .001, odds ratio ¼ 3.17, 95% confidence interval 2.45-4.09). However, the association was not found in East Asian population.
In our study, we found that TREM2 variant is likely not associated with AD in East Asian population.
大规模全基因组关联研究已确定髓系细胞触发受体2（TREM2）变异与白种人群中的阿尔茨海默病（AD）显著相关。本系统研究和荟萃分析的目的是评估东亚人群中髓系细胞触发受体2（TREM2）变异与AD之间的关联。
在本研究中，检索了PubMed、MEDLINE、EMBASE和Cochrane图书馆中的文献，以筛选1990年1月至2014年6月的引文。使用Stata 12软件进行数据分析。
共纳入12项研究进行分析。共研究了13535例AD患者和22976例健康对照。结果显示，rs75932628变异在白种人群中与AD显著相关（P <.001，比值比¼ 3.17，95%置信区间2.45 - 4.09）。然而，在东亚人群中未发现这种关联。
在我们的研究中，我们发现TREM2变异在东亚人群中可能与AD无关。
