Department of Health Promotion, Education, and Behavior, University of South Carolina, Columbia, SC, United States.
Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, United States.
Front Public Health. 2021 Dec 24;9:784958. doi: 10.3389/fpubh.2021.784958. eCollection 2021.
As the United States (U.S.) population rapidly ages, the incidence of Alzheimer's Disease and Related Dementias (ADRDs) is rising, with racial/ethnic minorities affected at disproportionate rates. Much research has been undertaken to test, sequence, and analyze genetic risk factors for ADRDs in Caucasian populations, but comparatively little has been done with racial/ethnic minority populations. We conducted a scoping review to examine the nature and extent of the research that has been published about the genetic factors of ADRDs among racial/ethnic minorities in the U.S. Using an established scoping review methodological framework, we searched electronic databases for articles describing peer-reviewed empirical studies or Genome-Wide Association Studies that had been published 2005-2018 and focused on ADRD-related genes or genetic factors among underrepresented racial/ethnic minority population in the U.S. Sixty-six articles met the inclusion criteria for full text review. Well-established ADRD genetic risk factors for Caucasian populations including , and have not been studied to the same degree in minority U.S. populations. Compared to the amount of research that has been conducted with Caucasian populations in the U.S., racial/ethnic minority communities are underrepresented. Given the projected growth of the aging population and incidence of ADRDs, particularly among racial/ethnic minorities, increased focus on this important segment of the population is warranted. Our review can aid researchers in developing fundamental research questions to determine the role that ADRD risk genes play in the heavier burden of ADRDs in racial/ethnic minority populations.
随着美国人口的迅速老龄化，阿尔茨海默病和相关痴呆症（ADRDs）的发病率正在上升，少数族裔的发病率不成比例地上升。已经进行了大量研究来测试、测序和分析高加索人群中 ADRD 的遗传风险因素，但对少数族裔人群的研究相对较少。我们进行了一项范围综述，以检查已经发表的关于美国少数族裔 ADRD 遗传因素的研究的性质和范围。 使用既定的范围综述方法框架，我们搜索了电子数据库，以查找描述已发表的同行评审实证研究或全基因组关联研究的文章，这些研究的重点是美国代表性不足的少数族裔人群中的 ADRD 相关基因或遗传因素。 符合全文审查标准的有 66 篇文章。已经在高加索人群中进行了研究的公认的 ADRD 遗传风险因素，包括 和 ，尚未在少数族裔美国人群中进行同样程度的研究。与在美国进行的针对高加索人群的研究相比，少数族裔社区的代表性不足。 鉴于老龄化人口和 ADRDs 的发病率预计会增长，特别是在少数族裔中，需要更加关注这一重要人群。我们的综述可以帮助研究人员提出基本的研究问题，以确定 ADRD 风险基因在少数族裔人群中 ADRD 负担加重中所起的作用。
