溶血磷脂酸信号传导在发育过程中的作用
Lysophosphatidic acid signalling in development.
作者信息
Sheng Xiaoyan, Yung Yun C, Chen Allison, Chun Jerold
机构信息
Molecular and Cellular Neuroscience Department, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA.
Molecular and Cellular Neuroscience Department, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA 92037, USA
出版信息
Development. 2015 Apr 15;142(8):1390-5. doi: 10.1242/dev.121723.
Abstract
Lysophosphatidic acid (LPA) is a bioactive phospholipid that is present in all tissues examined to date. LPA signals extracellularly via cognate G protein-coupled receptors to mediate cellular processes such as survival, proliferation, differentiation, migration, adhesion and morphology. These LPA-influenced processes impact many aspects of organismal development. In particular, LPA signalling has been shown to affect fertility and reproduction, formation of the nervous system, and development of the vasculature. Here and in the accompanying poster, we review the developmentally related features of LPA signalling.
摘要
溶血磷脂酸（LPA）是一种生物活性磷脂，迄今为止在所有检测过的组织中均有存在。LPA通过同源G蛋白偶联受体在细胞外发出信号，以介导诸如存活、增殖、分化、迁移、黏附和形态等细胞过程。这些受LPA影响的过程会影响机体发育的许多方面。特别是，LPA信号已被证明会影响生育和繁殖、神经系统的形成以及脉管系统的发育。在本文以及随附的海报中，我们将综述LPA信号与发育相关的特征。
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