Patel Urmeel H, Mir Muhammad A, Sivik Jeffrey K, Raheja Divisha, Pandey Manoj K, Talamo Giampaolo
Penn State Hershey Cancer Institute , Hershey, PA, USA.
Hematol Rep. 2015 Mar 3;7(1):5704. doi: 10.4081/hr.2015.5704. eCollection 2015 Feb 24.
Immunomodulatory drugs (IMiDs) currently used in the treatment of multiple myeloma, are thalidomide, lenalidomide and pomalidomide. One of the most common side effects of thalidomide is neurotoxicity, predominantly in the form of peripheral neuropathy. We report 6 cases of significant central neurotoxicity associated with IMiD therapy. Treatment with thalidomide (1 patient), lenalidomide (4 patients), and pomalidomide (1 patient) was associated with various clinical manifestations of central neurotoxicity, including reversible coma, amnesia, expressive aphasia, and dysarthria. Central neurotoxicity should be recognized as an important side effect of IMiD therapy.
目前用于治疗多发性骨髓瘤的免疫调节药物(IMiDs)有沙利度胺、来那度胺和泊马度胺。沙利度胺最常见的副作用之一是神经毒性,主要表现为周围神经病变。我们报告了6例与IMiD治疗相关的严重中枢神经毒性病例。使用沙利度胺(1例患者)、来那度胺(4例患者)和泊马度胺(1例患者)治疗与中枢神经毒性的各种临床表现相关,包括可逆性昏迷、失忆、表达性失语和构音障碍。中枢神经毒性应被视为IMiD治疗的一种重要副作用。