Giammanco Marco, Di Majo Danila, La Guardia Maurizio, Aiello Stefania, Crescimannno Marilena, Flandina Carla, Tumminello Francesca M, Leto Gaetano
Unit of Physiology and Pharmacology, DIGISPO and.
Pharm Biol. 2015;53(10):1399-434. doi: 10.3109/13880209.2014.988274. Epub 2015 Apr 9.
There is increasing evidence that Vitamin D (Vit D) and its metabolites, besides their well-known calcium-related functions, may also exert antiproliferative, pro-differentiating, and immune modulatory effects on tumor cells in vitro and may also delay tumor growth in vivo.
The aim of this review is to provide fresh insight into the most recent advances on the role of Vit D and its analogues as chemopreventive drugs in cancer therapy.
A systematic review of experimental and clinical studies on Vit D and cancer was undertaken by using the major electronic health database including ISI Web of Science, Medline, PubMed, Scopus and Google Scholar.
Experimental and clinical observations suggest that Vit D and its analogues may be effective in preventing the malignant transformation and/or the progression of various types of human tumors including breast cancer, prostate cancer, colorectal cancer, and some hematological malignances. These findings suggest the possibility of the clinical use of these molecules as novel potential chemopreventive and anticancer agents.
越来越多的证据表明，维生素D（Vit D）及其代谢产物，除了其众所周知的与钙相关的功能外，在体外对肿瘤细胞可能还具有抗增殖、促分化和免疫调节作用，并且在体内可能还会延缓肿瘤生长。
本综述的目的是对Vit D及其类似物作为癌症治疗中化学预防药物的作用的最新进展提供新的见解。
通过使用包括ISI Web of Science、Medline、PubMed、Scopus和谷歌学术在内的主要电子健康数据库，对关于Vit D与癌症的实验和临床研究进行了系统综述。
实验和临床观察表明，Vit D及其类似物可能有效地预防包括乳腺癌、前列腺癌、结直肠癌和一些血液系统恶性肿瘤在内的各种类型人类肿瘤的恶性转化和/或进展。这些发现提示了将这些分子作为新型潜在化学预防和抗癌药物临床应用的可能性。
