Rösch Sarah, Woitas Julia, Oechtering Gerhard Ulrich
Ear, Nose and Throat Unit, Small Animal Department, Faculty of Veterinary Medicine, Leipzig University, 04103 Leipzig, Germany.
Animals (Basel). 2024 Oct 9;14(19):2908. doi: 10.3390/ani14192908.
In this prospective blinded study, canine C-reactive protein (c-CRP), haptoglobin (HPT), and 25-hydroxyvitamin-D (25(OH)D) were investigated for their diagnostic value in 55 dogs with nasal cavity disease (ND). After comprehensive diagnostics including a culture-dependent microbiological examination (ME) of nasal swabs, 17 dogs were excluded due to additionally detected systemic diseases or steroid pre-treatment. Included were 25 dogs with malignant ND (13 carcinomas and 12 sarcomas) and 30 dogs with benign ND (7 benign tumors, 13 idiopathic rhinitis (IR), and 10 others), as well as 10 controls. In none of the 72 dogs with ND was primary bacterial rhinitis diagnosed. Although within the reference interval, compared to the controls, c-CRP was significantly higher in dogs with ND in general and in every subgroup except for benign tumors. Serum HPT concentrations were not different among groups. Compared to the controls, 25(OH)D concentrations were significantly lower ( = 0.041) in malignant ND and sarcomas ( = 0.025). Despite pre-treatment with antibiotics (40/54; 74.1%), in 23/51 (45%) dogs, the ME was positive. Cultivated bacteria did not differ significantly between nasal diseases. The serum markers were not significantly different regarding the positivity of ME. In conclusion, the investigated serum markers were not clinically useful for the reliable detection of canine ND, as was the ME. Because of the low number of dogs with IR and positive or negative ME, further studies regarding c-CRP are needed in a larger group of IR dogs without concomitant diseases to reliably evaluate its utility in IR dogs with suspected secondary bacterial nasal infection.
在这项前瞻性盲法研究中，对犬C反应蛋白（c-CRP）、触珠蛋白（HPT）和25-羟基维生素D（25(OH)D）在55只患有鼻腔疾病（ND）的犬中的诊断价值进行了研究。在进行包括鼻拭子的培养依赖性微生物学检查（ME）在内的综合诊断后，17只犬因额外检测出全身性疾病或类固醇预处理而被排除。纳入研究的有25只患有恶性ND的犬（13只癌和12只肉瘤）、30只患有良性ND的犬（7只良性肿瘤、13只特发性鼻炎（IR）和10只其他疾病）以及10只对照犬。在72只患有ND的犬中，均未诊断出原发性细菌性鼻炎。虽然c-CRP在参考区间内，但与对照组相比，一般患有ND的犬以及除良性肿瘤外的每个亚组中的c-CRP均显著更高。各组间血清HPT浓度无差异。与对照组相比，恶性ND和肉瘤中的25(OH)D浓度显著更低（P = 0.041）（P = 0.025）。尽管使用了抗生素进行预处理（40/54；74.1%），但在23/51（45%）的犬中，ME呈阳性。鼻腔疾病之间培养出的细菌无显著差异。血清标志物在ME阳性方面无显著差异。总之，所研究的血清标志物在可靠检测犬ND方面在临床上并无用处，ME也是如此。由于患有IR且ME阳性或阴性的犬数量较少，因此需要在更大的无伴发疾病的IR犬群体中进一步研究c-CRP，以可靠评估其在疑似继发性细菌性鼻感染的IR犬中的效用。
