聚焦前列腺癌：最新证据与当前争议

Spotlight on prostate cancer: the latest evidence and current controversies.

作者信息

Carlsson Sigrid, Vickers Andrew

出版信息

BMC Med. 2015 Mar 24;13:60. doi: 10.1186/s12916-015-0311-x.

DOI:10.1186/s12916-015-0311-x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4372269/

Abstract

Recent decades have seen dramatic changes in the management of prostate cancer based on novel research findings. Prostate-specific antigen (PSA) screening has been introduced, and then recently modified to include new strategies and biomarkers. Management of advanced disease has been transformed by the rapid introduction of new agents. We have moved from a "one-size-fits-all" approach in prostate cancer management to multidisciplinary strategies tailored to the individual patient and his specific cancer. This editorial marks the launch of the article collection Spotlight on prostate cancer (http://www.biomedcentral.com/bmcmed/series/SPR), and here, guest editors Sigrid Carlsson and Andrew Vickers give an overview of the past, present, and future of prostate cancer research and management.

摘要

近几十年来，基于新的研究发现，前列腺癌的管理发生了巨大变化。前列腺特异性抗原（PSA）筛查已经引入，并且最近进行了改进，纳入了新的策略和生物标志物。新药物的迅速推出改变了晚期疾病的管理方式。我们已经从前列腺癌管理的“一刀切”方法转向了针对个体患者及其特定癌症的多学科策略。这篇社论标志着文章合集《聚焦前列腺癌》（http://www.biomedcentral.com/bmcmed/series/SPR）的推出，在此，客座编辑西格丽德·卡尔松和安德鲁·维克斯对前列腺癌研究与管理的过去、现在和未来进行了概述。

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本文引用的文献

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Nutrition, dietary interventions and prostate cancer: the latest evidence.营养、饮食干预与前列腺癌：最新证据

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N Engl J Med. 2014 Mar 6;370(10):932-42. doi: 10.1056/NEJMoa1311593.

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Eur J Cancer. 2013 Apr;49(6):1374-403. doi: 10.1016/j.ejca.2012.12.027. Epub 2013 Feb 26.

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Radical prostatectomy versus observation for localized prostate cancer.根治性前列腺切除术与观察等待治疗局限性前列腺癌的比较。

N Engl J Med. 2012 Jul 19;367(3):203-13. doi: 10.1056/NEJMoa1113162.

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Screening for prostate cancer: U.S. Preventive Services Task Force recommendation statement.前列腺癌筛查：美国预防服务工作组推荐声明。

Ann Intern Med. 2012 Jul 17;157(2):120-34. doi: 10.7326/0003-4819-157-2-201207170-00459.

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Prostate cancer screening in the randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: mortality results after 13 years of follow-up.随机前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验中的前列腺癌筛查：13 年随访后的死亡率结果。

J Natl Cancer Inst. 2012 Jan 18;104(2):125-32. doi: 10.1093/jnci/djr500. Epub 2012 Jan 6.

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