Roussin Anne, Doazan-d'Ouince Odile, Géniaux Hélène, Halberer Clémence
Centre d'Évaluation et d'Information sur la Pharmacodépendance (Centre d'Addictovigilance), Service de Pharmacologie Clinique, Hôpitaux de Toulouse, Toulouse, France - Pharmacoépidémiologie, UMR1027 INSERM - Université de Toulouse III, Toulouse, France.
Pharmacoépidémiologie, UMR1027 INSERM - Université de Toulouse III, Toulouse, France.
Therapie. 2015 Mar-Apr;70(2):203-21. doi: 10.2515/therapie/2015014. Epub 2015 Apr 9.
The objective of this paper is to present an evaluation of the potential for abuse of and dependence on a drug from the data obtained from the different pharmacoepidemiological tools used by the French network for evaluation and information on pharmacodependence and addiction monitoring taking the example of tramadol. Comparison of the data from spontaneous reports with surveys in specific populations and with evaluations of indicators of diverted uses does not highlight a major problem of tramadol abuse and dependence in terms of public health, but stresses the importance of paying attention to the signal. This example of addiction monitoring of tramadol illustrates the interest of comparing results obtained from different validated sources. The implementation of repeated observational programs of abuse of and dependence on psychoactive drugs is an important aid to health authorities to define the content of the information to be delivered or regulatory decisions to reduce these problematic uses.
本文的目的是，以曲马多为例，根据法国药物依赖与成瘾监测评估和信息网络所使用的不同药物流行病学工具获得的数据，对一种药物的滥用和依赖可能性进行评估。将自发报告的数据与特定人群调查的数据以及转移用途指标评估的数据进行比较，并未凸显出曲马多滥用和依赖在公共卫生方面的重大问题，但强调了关注该信号的重要性。曲马多成瘾监测的这个例子说明了比较从不同经过验证的来源获得的结果的意义。实施关于精神活性药物滥用和依赖的重复观察项目，对卫生当局确定要提供的信息内容或为减少这些有问题的使用而做出监管决策有重要帮助。
