Department of Surgical Oncology, Institute of Oncology, Zaloska 2, 1000, Ljubljana, Slovenia.
Faculty of Mathematics and Physics, University of Ljubljana, 1000, Ljubljana, Slovenia.
Sci Rep. 2020 Oct 30;10(1):18766. doi: 10.1038/s41598-020-75961-2.
The objective of this study was to evaluate the severity of acute pain and side effects in breast cancer patients postoperatively treated with two regimens of tramadol with paracetamol in a prospective double-blind study. Altogether 117 breast cancer patients who had axillary lymphadenectomy were randomized into two analgesic study groups and the analgesic treatment lasted 4 weeks. Stronger analgesia group received every 8 h 75/650 mg of tramadol with paracetamol, while weaker analgesia group received every 8 h 37.5/325 mg of tramadol with paracetamol. Patients with the higher dose of tramadol had less pain during the 1st and 4th week than patients with the lower dose. Frequency of nausea, vomiting, lymphedema or range of shoulder movement was not significantly different between the two groups of patients. Constipation was significantly more common in the group with stronger analgesia during the 2nd week in comparison to patients with weaker analgesia. The patients who were on 75/650 mg of tramadol with paracetamol had less pain in comparison to patients who were on 37.5/325 mg. Side effects were mild, but common in both groups of patients.
本研究旨在评估两种曲马多联合对乙酰氨基酚方案治疗乳腺癌术后患者急性疼痛和不良反应的严重程度。在一项前瞻性双盲研究中，共纳入 117 例接受腋窝淋巴结清扫术的乳腺癌患者，随机分为两组接受镇痛治疗，持续 4 周。强镇痛组每 8 小时给予 75/650mg 曲马多联合对乙酰氨基酚，弱镇痛组每 8 小时给予 37.5/325mg 曲马多联合对乙酰氨基酚。高剂量曲马多组患者在第 1 周和第 4 周的疼痛程度低于低剂量组。两组患者的恶心、呕吐、淋巴水肿或肩部活动范围的发生率无显著差异。与弱镇痛组相比，强镇痛组在第 2 周的便秘发生率明显更高。与 37.5/325mg 组相比，接受 75/650mg 曲马多联合对乙酰氨基酚的患者疼痛程度更低。两组患者的不良反应均为轻度，但较为常见。
