Matsuhashi H, Onodera S, Kawamura Y, Hasebe N, Kohmura C, Yamashita H, Tobise K
First Department of Internal Medicine, Asahikawa Medical College, Japan.
Jpn J Med. 1989 Sep-Oct;28(5):612-5. doi: 10.2169/internalmedicine1962.28.612.
Probucol administration of 4 weeks produced torsades de pointes associated with exacerbated QT interval prolongation in a 36-year-old woman with Romano-Ward syndrome. With discontinuance of probucol, the QT interval corrected for rate shortened from 620 msec to 500 msec and ventricular ectopic beats disappeared completely. Although probucol is known to prolong the QT interval, associated ventricular tachyarrhythmia has not been reported in humans as yet. This case suggests that one should be very careful in the administration of probucol to patients with long baseline QT intervals.
一名患有 Romano-Ward 综合征的 36 岁女性服用普罗布考 4 周后出现尖端扭转型室速，同时 QT 间期延长加剧。停用普罗布考后，校正心率后的 QT 间期从 620 毫秒缩短至 500 毫秒，室性早搏完全消失。虽然已知普罗布考会延长 QT 间期，但人类中尚未有相关室性快速心律失常的报道。该病例提示，对于基线 QT 间期较长的患者，使用普罗布考时应格外谨慎。
