Lam Tai Hing, Cheung Yee Tak Derek, Leung Doris Yin Ping, Abdullah Abu Saleh M, Chan Sophia Siu Chee
School of Public Health, The University of Hong Kong, Hong Kong, China.
The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong, China.
Tob Induc Dis. 2015 Apr 2;13(1):9. doi: 10.1186/s12971-015-0034-y. eCollection 2015.
The prevalence and correlates of hardcore smokers, who have high daily cigarette consumption, no quitting history and no intention to quit, have been studied in several western developed countries, but no previous trials of smoking cessation have tested intervention effectiveness for these smokers. The current study examined if hardcore smokers can benefit from smoking reduction intervention to achieve cessation, and explored the underlying reasons.
A posteriori analysis was conducted on data from a randomized controlled trial of smoking reduction intervention on 1,154 smokers who did not want to quit. Odds ratios of 7-day point prevalence of abstinence, smoking reduction by at least 50% and quit attempt at the 6-month follow-up comparing subgroups of smokers were analyzed.
In hardcore smokers, the odds ratio comparing the quit rate between the intervention and control group was 4.18 (95% CI: 0.51-34.65), which was greater than non-hardcore smokers (OR = 1.58, 95% CI: 0.98-2.54). The number needed to treat for hardcore and non-hardcore smokers was 8.33 (95% CI: 5.56-16.67) and 16.67 (95% CI: 8.33-233.64), respectively. In smokers who did not have quit attempt experience and those who smoked more than 15 cigarettes daily, the odds ratio comparing intervention and control group was 3.29 (95% CI: 0.72-14.98) and 1.36 (95% CI: 0.78-2.36), respectively.
The a posteriori analysis provided pilot results that smoking reduction intervention may be effective to help hardcore smokers to quit and reduce smoking. Having no previous quit attempt was identified as more important than having large cigarette consumption in explaining the greater effectiveness of the intervention.
在几个西方发达国家,对重度吸烟者(即每日吸烟量高、无戒烟史且无意戒烟者)的患病率及其相关因素进行了研究,但此前尚无戒烟试验检验针对这些吸烟者的干预效果。本研究检验了重度吸烟者是否能从减少吸烟干预中获益以实现戒烟,并探究了其潜在原因。
对一项针对1154名无意戒烟者的减少吸烟干预随机对照试验的数据进行事后分析。分析了在6个月随访时比较吸烟者亚组的7天时点戒烟率、至少减少50%吸烟量和尝试戒烟的比值比。
在重度吸烟者中,干预组与对照组戒烟率的比值比为4.18(95%置信区间:0.51 - 34.65),高于非重度吸烟者(比值比 = 1.58,95%置信区间:0.98 - 2.54)。重度吸烟者和非重度吸烟者的治疗所需人数分别为8.33(95%置信区间:5.56 - 16.67)和16.67(95%置信区间:8.33 - 233.64)。在没有尝试戒烟经历的吸烟者和每日吸烟超过15支的吸烟者中,干预组与对照组的比值比分别为3.29(95%置信区间:0.72 - 14.98)和1.36(95%置信区间:0.78 - 2.36)。
事后分析提供了初步结果,表明减少吸烟干预可能有效帮助重度吸烟者戒烟和减少吸烟量。在解释干预效果更好的原因时,未尝试过戒烟比吸烟量大更为重要。