Chen Wei, Hu Guo-Hua
Department of Otorhinolaryngology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Cancer Biol Med. 2015 Mar;12(1):23-32. doi: 10.7497/j.issn.2095-3941.2014.0015.
Nasopharyngeal carcinoma (NPC) is a common head and neck malignancy. The incidence of NPC is higher in Southern China and Southeast Asia compared with Western countries. Given its high radiosensitivity, the standard treatment for NPC is radiotherapy. However, radioresistance remains a serious obstacle to successful treatment. Radioresistance can cause local recurrence and distant metastases in some patients after treatment by radiation. Thus, special emphasis has been given to the discovery of effective radiosensitizers. This review aims to discuss the biomarkers, classified according to the main mechanisms of radiosensitization, which can enhance the sensitivity of NPC cells to ionizing radiation.
鼻咽癌（NPC）是一种常见的头颈部恶性肿瘤。与西方国家相比，中国南方和东南亚地区的鼻咽癌发病率更高。鉴于其高放射敏感性，鼻咽癌的标准治疗方法是放射治疗。然而，放射抗性仍然是成功治疗的严重障碍。放射抗性可导致一些患者在接受放射治疗后出现局部复发和远处转移。因此，人们特别重视发现有效的放射增敏剂。本综述旨在讨论根据放射增敏的主要机制分类的生物标志物，这些生物标志物可增强鼻咽癌细胞对电离辐射的敏感性。
