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胃癌化疗后SPARC表达的变化。

Change of SPARC expression after chemotherapy in gastric cancer.

作者信息

Gao Yong-Yin, Han Ru-Bing, Wang Xia, Ge Shao-Hua, Li Hong-Li, Deng Ting, Liu Rui, Bai Ming, Zhou Li-Kun, Zhang Xin-Yuan, Ba Yi, Huang Ding-Zhi

机构信息

Department of Gastrointestinal Medical Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.

出版信息

Cancer Biol Med. 2015 Mar;12(1):33-40. doi: 10.7497/j.issn.2095-3941.2014.0023.

DOI:10.7497/j.issn.2095-3941.2014.0023
PMID:25859409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4383841/
Abstract

OBJECTIVE

The expression of tumor biomarkers may change after chemotherapy. However, whether secreted protein acidic and rich in cysteine (SPARC) expression changes after chemotherapy in gastric cancer (GC) is unclear. This study investigated the influence of chemotherapy on SPARC expression in GC.

METHODS

Immunohistochemistry was used to analyze SPARC expression in 132 GC cases (including 54 cases with preoperative chemotherapy and 78 cases without preoperative chemotherapy). SPARC expression of postoperative specimens with and without preoperative chemotherapy was assessed to analyze the influence of chemotherapy on SPARC expression.

RESULTS

SPARC was highly expressed in GC compared with the desmoplastic stroma surrounding tumor cells and noncancerous tissues. High SPARC expression was correlated with invasion depth, lymph node, and TNM stage. After chemotherapy, a lower proportion of high SPARC expression was observed in patients with preoperative chemotherapy than in the controls. For 54 patients with preoperative chemotherapy, gross type, histology, depth of invasion, lymph node, TNM stage, and SPARC expression were related to overall survival. Further multivariate analysis showed that lymph node, histology, and SPARC expression after chemotherapy were independent prognostic factors.

CONCLUSION

SPARC expression may change after chemotherapy in GC. SPARC expression should be reassessed for patients with GC after chemotherapy.

摘要

目的

肿瘤生物标志物的表达在化疗后可能会发生变化。然而，胃癌（GC）化疗后富含半胱氨酸的酸性分泌蛋白（SPARC）的表达是否改变尚不清楚。本研究调查了化疗对GC中SPARC表达的影响。

方法

采用免疫组织化学分析132例GC病例（包括54例术前化疗病例和78例未进行术前化疗病例）中SPARC的表达。评估术前化疗和未进行术前化疗的术后标本中SPARC的表达，以分析化疗对SPARC表达的影响。

结果

与肿瘤细胞周围的促结缔组织增生性基质和非癌组织相比，SPARC在GC中高表达。SPARC高表达与浸润深度、淋巴结及TNM分期相关。化疗后，术前化疗患者中SPARC高表达的比例低于对照组。对于54例术前化疗患者，大体类型、组织学、浸润深度、淋巴结、TNM分期及SPARC表达与总生存期相关。进一步多因素分析显示，化疗后的淋巴结、组织学及SPARC表达是独立的预后因素。

结论

GC化疗后SPARC表达可能发生变化。GC患者化疗后应重新评估SPARC表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbd/4383841/cf4744cb1c5e/cbm-12-033-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbd/4383841/1efa29e3f2ed/cbm-12-033-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbd/4383841/b2a19d514fca/cbm-12-033-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbd/4383841/2af7b3e01a2d/cbm-12-033-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbd/4383841/cf4744cb1c5e/cbm-12-033-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbd/4383841/1efa29e3f2ed/cbm-12-033-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbd/4383841/b2a19d514fca/cbm-12-033-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbd/4383841/2af7b3e01a2d/cbm-12-033-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bbd/4383841/cf4744cb1c5e/cbm-12-033-g004.jpg

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2
Phase II trial of nanoparticle albumin-bound paclitaxel as second-line chemotherapy for unresectable or recurrent gastric cancer.白蛋白结合型紫杉醇纳米粒二线治疗不可切除或复发性胃癌的 II 期临床试验。
Cancer Sci. 2014 Jul;105(7):812-7. doi: 10.1111/cas.12419. Epub 2014 Jul 7.
3
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4
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5
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SPARC expression in patients with high-risk localized soft tissue sarcoma treated on a randomized phase II trial of neo/adjuvant chemotherapy.在一项新辅助/辅助化疗随机II期试验中接受治疗的高危局限性软组织肉瘤患者中的SPARC表达。
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