Department of Neurology, Chinese People's Liberation Army General Hospital, No. 28, Fuxing Road, Haidian District, Beijing, 100853, China,
J Neurol. 2015 Jun;262(6):1440-6. doi: 10.1007/s00415-015-7723-6. Epub 2015 Apr 11.
The objective of this study is to investigate the hyperintense lesions on diffusion-weighted magnetic resonance imaging (DWI) and its clinical correlation in sporadic Creutzfeldt-Jakob disease (sCJD). Patients who suffered from sCJD and followed up at the Department of Neurology at the General Hospital of the People's Liberation Army during the period of June 1, 2007 to July 1, 2014 were reviewed. The location of the hyperintense lesions on DWI, apparent diffusion coefficient (ADC) values of the hyperintense lesions were correlated with symptoms and clinical course. A total of 58 sCJD patients and ten healthy controls were included. Hyperintense lesions on DWI were observed in all the patients. The patients with basal ganglia (BG) hyperintense lesions on DWI had shorter disease duration and higher incidence of myoclonus (92 versus 44 %) than those without BG hyperintense lesions. The patients with occipital cortex hyperintense lesions on DWI had shorter disease duration between symptom onset and akinetic mutism than those without these lesions. The lower of the BG ADC value the faster presence of akinetic mutism and the shorter disease duration the patients will have. The presence of BG and occipital cortex hyperintense lesions on DWI and BG ADC values is correlated with the clinical course and clinical symptoms.
本研究旨在探讨散发性克雅氏病（sCJD）患者磁共振弥散加权成像（DWI）上高信号病灶及其与临床的相关性。回顾性分析 2007 年 6 月 1 日至 2014 年 7 月 1 日期间在解放军总医院神经内科就诊的 sCJD 患者。分析 DWI 上高信号病灶的位置、表观弥散系数（ADC）值与症状及临床病程的相关性。共纳入 58 例 sCJD 患者和 10 例健康对照者。所有患者 DWI 上均可见高信号病灶。基底节区（BG）DWI 高信号病灶患者的病程更短，肌阵挛发生率更高（92%比 44%）；而脑叶 DWI 高信号病灶患者的起病至无动性缄默期的病程更短。BG 的 ADC 值越低，出现无动性缄默的时间越早，病程越短。BG 和脑叶 DWI 高信号病灶及 BG ADC 值与临床病程和临床症状相关。
