番石榴叶中的细胞毒性和抗氧化成分。
Cytotoxic and antioxidant constituents from the leaves of Psidium guajava.
作者信息
Feng Xiao-He, Wang Zi-Hao, Meng Da-Li, Li Xian
机构信息
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China.
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China.
出版信息
Bioorg Med Chem Lett. 2015;25(10):2193-8. doi: 10.1016/j.bmcl.2015.03.058. Epub 2015 Mar 26.
Psidium guajava (Myrtaceae) is an evergreen shrub growing extensively throughout the tropical and subtropical areas. Four new compounds, guavinoside C, D, E and F (1-3, 10) were isolated from the leaves of P. guajava, along with six known ones (4-9). Their structures were elucidated by spectroscopic analysis. Compounds 1, 4 and 10 showed significant cytotoxic activities on HeLa, SGC-7901 and A549 cell lines, respectively. Compounds 1 and 4-10 showed antioxidant activities in DPPH, ABTS and FRAP assays, and five of them (1, 4-6, 10) exhibited stronger activities than that of vitamin C.
番石榴（桃金娘科）是一种常绿灌木，广泛生长于热带和亚热带地区。从番石榴叶中分离出了四种新化合物，番石榴苷C、D、E和F（1 - 3，10），以及六种已知化合物（4 - 9）。通过光谱分析确定了它们的结构。化合物1、4和10分别对HeLa、SGC - 7901和A549细胞系显示出显著的细胞毒性活性。化合物1和4 - 10在DPPH、ABTS和FRAP测定中表现出抗氧化活性，其中五种（1、4 - 6、10）表现出比维生素C更强的活性。
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