Magno Marcela Baraúna, Nascimento Gláucia Cristina Rodrigues, Da Penha Natasha Kiss Santos, Pessoa Oscar Faciola, Loretto Sandro Cordeiro, Maia Lucianne Cople
Am J Dent. 2015 Feb;28(1):40-4.
To present an overview of clinical evidence of strontium acetate and arginine-based toothpastes, in order to determine which of these substances was the most effective to relieve dentin hypersensitivity (DH).
An electronic search was performed in PubMed, EMBASE, The Cochrane Library, LILACS, Web of Science and Open Grey databases. The search strategy included MeSH terms, synonyms and keywords with no language or date restriction. Randomized controlled clinical trial studies that compared the effectiveness of arginine/calcium carbonate and strontium acetate toothpaste were included. The risk of bias in the included studies was assessed and classified through the Cochrane Collaboration's common scheme for bias. Data were subgrouped and heterogeneity was tested via comprehensive meta-analysis.
A total of 3,883 potentially relevant studies were identified. After title and abstract examination, only six studies fulfilled the eligibility criteria and were classified as having a "low risk of bias". The majority of studies found better results for arginine/calcium carbonate in comparison with strontium acetate in alleviating DH. Only one study reported superior efficacy of strontium acetate, and only for tactile stimuli, after 8 weeks of home use. The arginine/calcium carbonate-based toothpaste provided a higher level of efficacy in terms of DH relief than the strontium-based toothpaste.
概述乙酸锶和精氨酸牙膏的临床证据，以确定哪种物质在缓解牙本质过敏症（DH）方面最有效。
在PubMed、EMBASE、Cochrane图书馆、LILACS、科学网和Open Grey数据库中进行电子检索。检索策略包括医学主题词、同义词和关键词，无语言或日期限制。纳入比较精氨酸/碳酸钙牙膏和乙酸锶牙膏有效性的随机对照临床试验研究。通过Cochrane协作网的常见偏倚评估方案对纳入研究的偏倚风险进行评估和分类。数据进行亚组分析，并通过综合荟萃分析检验异质性。
共识别出3883项潜在相关研究。经标题和摘要审查后，仅有6项研究符合纳入标准，被归类为“低偏倚风险”。大多数研究发现，与乙酸锶相比，精氨酸/碳酸钙在缓解牙本质过敏症方面效果更好。只有一项研究报告称，在家使用8周后，乙酸锶仅在触觉刺激方面具有更高疗效。基于精氨酸/碳酸钙的牙膏在缓解牙本质过敏症方面比基于锶的牙膏具有更高的疗效水平。
