Kimura O, Murata Y, Shiota S, Makino M, Nishidoi H, Kaibara N, Koga S
First Department of Surgery, Tottori University School of Medicine, Yonago, Japan.
Nihon Geka Gakkai Zasshi. 1989 Sep;90(9):1564-7.
Nuclear DNA content was microspectrophotometrically measured in 120 gastric cancer patients to assess the predominance of a particular DNA distribution pattern in gastric cancer with biologically high malignancy, such as the marked tendency for severe vessel invasion and remote metastasis, and for early recurrence after curative surgery. DNA distribution patterns were grouped into low and high ploidies, and the correlation between the DNA ploidy pattern and histopathologic, biologic findings was evaluated. The incidence of high DNA ploidy tended to be increased as the histological stage and level of infiltration progressed. On the other hand, the incidence of high DNA ploidy was higher in dead cases of early recurrence among cases of the same histological stage, or where vessel invasion and remote metastasis were severe among cases of the same depth of invasion. Therefore, we consider that the DNA distribution pattern well reflects the malignancy of gastric cancer.
采用显微分光光度法对120例胃癌患者的核DNA含量进行检测，以评估具有高生物学恶性的胃癌中特定DNA分布模式的优势情况，例如严重血管侵犯和远处转移的明显倾向，以及根治性手术后早期复发的倾向。DNA分布模式分为低倍体和高倍体，并评估DNA倍体模式与组织病理学、生物学表现之间的相关性。随着组织学分期和浸润程度的进展，高DNA倍体的发生率呈上升趋势。另一方面，在相同组织学分期的病例中，早期复发死亡病例的高DNA倍体发生率更高，或者在相同浸润深度的病例中，血管侵犯和远处转移严重的病例中高DNA倍体发生率更高。因此，我们认为DNA分布模式能很好地反映胃癌的恶性程度。
