Lu Jianning, Luo Ceng, Bali Kiran Kumar, Xie Rou-Gang, Mains Richard E, Eipper Betty A, Kuner Rohini
Department of Molecular Pharmacology, Pharmacology Institute, Medical Faculty Heidelberg, Heidelberg University, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany.
Institute of Neuroscience, Fourth Military Medical University, 17 West Chang-le Road, Xi'an 710032, China.
Nat Commun. 2015 Apr 13;6:6820. doi: 10.1038/ncomms7820.
Synaptic plasticity is the cornerstone of processes underlying persistent nociceptive activity-induced changes in normal nociceptive sensitivity. Kalirin-7 is a multifunctional guanine-nucleotide-exchange factor (GEF) for Rho GTPases that is characterized by its localization at excitatory synapses, interactions with glutamate receptors and its ability to dynamically modulate the neuronal cytoskeleton. Here we show that spinally expressed Kalirin-7 is required for persistent nociceptive activity-dependent synaptic long-term potentiation as well as activity-dependent remodelling of synaptic spines in the spinal dorsal horn, thereby orchestrating functional and structural plasticity during the course of inflammatory pain.
突触可塑性是正常伤害性感受敏感性中持续性伤害性活动诱导变化所依赖过程的基石。Kalirin-7是一种针对Rho GTP酶的多功能鸟嘌呤核苷酸交换因子（GEF），其特点是定位于兴奋性突触，与谷氨酸受体相互作用，并具有动态调节神经元细胞骨架的能力。在这里，我们表明，脊髓中表达的Kalirin-7是持续性伤害性活动依赖性突触长期增强以及脊髓背角突触棘的活动依赖性重塑所必需的，从而在炎症性疼痛过程中协调功能和结构可塑性。
