Rachakonda Vikrant P, Reeves Valerie L, Aljammal Jules, Wills Rachel C, Trybula Joy S, DeLany James P, Kienesberger Petra C, Kershaw Erin E
Division of Gastroenterology, Department of Medicine, University of Pittsburgh, Pennsylvania, USA; Division of Endocrinology, Department of Medicine, University of Pittsburgh, Pennsylvania, USA.
Obesity (Silver Spring). 2015 May;23(5):965-72. doi: 10.1002/oby.20960. Epub 2015 Apr 10.
Autotaxin (ATX) is an adipocyte-derived lysophospholipase that generates the lipid signaling molecule lysophosphatidic acid (LPA). The aim of this study was to determine the relationship between serum ATX and nonalcoholic fatty liver disease (NAFLD) in females with obesity.
101 nondiabetic women with obesity (age: 31.5-55.8 years; BMI: 35.0-64.5 kg/m2) were classified as having NAFLD (36.3%) or not having NAFLD (63.7%) based on the degree of hepatic steatosis on abdominal CT. Subjects were characterized for metabolic phenotype including measures of energy, glucose, and lipid homeostasis. Fasting serum adipokines and inflammatory markers were determined by ELISA. Linear regression analysis was used to determine features independently associated with NAFLD.
Subjects with and without NAFLD differed in several key features of metabolic phenotype including BMI, waist circumference, fasting glucose and insulin, HOMA-IR, VLDL, triglycerides, and ALT. Serum adipokines, including ATX and leptin, were higher in subjects with NAFLD. Serum ATX was significantly correlated with alkaline phosphatase, fasting glucose, fasting insulin, and HOMA-IR. Linear regression analysis revealed that serum triglycerides and log-transformed ATX were independently associated with hepatic steatosis.
Serum ATX may be a potential pathogenic factor and/or biomarker for NAFLD in nondiabetic women with obesity.
自分泌运动因子（ATX）是一种源自脂肪细胞的溶血磷脂酶，可生成脂质信号分子溶血磷脂酸（LPA）。本研究旨在确定肥胖女性血清ATX与非酒精性脂肪性肝病（NAFLD）之间的关系。
101名非糖尿病肥胖女性（年龄：31.5 - 55.8岁；BMI：35.0 - 64.5 kg/m²）根据腹部CT上肝脏脂肪变性程度分为患有NAFLD（36.3%）或未患有NAFLD（63.7%）。对受试者的代谢表型进行特征分析，包括能量、葡萄糖和脂质稳态指标。通过酶联免疫吸附测定法测定空腹血清脂肪因子和炎症标志物。采用线性回归分析确定与NAFLD独立相关的特征。
患有和未患有NAFLD的受试者在代谢表型的几个关键特征上存在差异，包括BMI、腰围、空腹血糖和胰岛素、HOMA-IR、极低密度脂蛋白、甘油三酯和谷丙转氨酶。包括ATX和瘦素在内的血清脂肪因子在患有NAFLD的受试者中较高。血清ATX与碱性磷酸酶、空腹血糖、空腹胰岛素和HOMA-IR显著相关。线性回归分析显示，血清甘油三酯和经对数转换的ATX与肝脏脂肪变性独立相关。
血清ATX可能是肥胖非糖尿病女性NAFLD的潜在致病因素和/或生物标志物。
