Hossain Israt Ara, Akter Salima, Rahman Mohammad Khalilur, Ali Liaquat
Department of Biochemistry and Cell Biology, Bangladesh University of Health Sciences, Dhaka, Bangladesh.
Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh.
PLoS One. 2015 Nov 16;10(11):e0142165. doi: 10.1371/journal.pone.0142165. eCollection 2015.
Adipose tissue-derived hormone leptin plays a functional role in glucose tolerance through its effects on insulin secretion and insulin sensitivity which also represent the risk factors for nonalcoholic fatty liver disease (NAFLD). The present study explored the gender specific association of serum leptin and insulinemic indices with NAFLD in Bangladeshi prediabetic subjects. Under a cross-sectional analytical design a total of 110 ultrasound examined prediabetic subjects, aged 25-68 years consisting of 57.3% male (55.6% non NAFLD and 44.4% NAFLD) and 42.7% female (57.4% non NAFLD and 42.6% NAFLD), were investigated. Insulin secretory function (HOMA%B) and insulin sensitivity (HOMA%S) were calculated from homeostasis model assessment (HOMA). Serum leptin showed significant positive correlation with fasting insulin (r = 0.530, P = 0.004), postprandial insulin (r = 0.384, P = 0.042) and HOMA-IR (r = 0.541, P = 0.003) as well as significant negative correlation with HOMA%S (r = -0.388, P = 0.046) and HOMA%B (r = -0.356, P = 0.039) in male prediabetic subjects with NAFLD. In multiple linear regression analysis, log transformed leptin showed significant positive association with HOMA-IR (β = 0.706, P <0.001) after adjusting the effects of body mass index (BMI), triglyceride (TG) and HOMA%B in male subjects with NAFLD. In binary logistic regression analysis, only log leptin [OR 1.29 95% (C.I) (1.11-1.51), P = 0.001] in male subjects as well as HOMA%B [OR 0.94 95% (C.I) (0.89-0.98), P = 0.012], HOMA-IR [OR 3.30 95% (C.I) (0.99-10.95), P = 0.049] and log leptin [OR 1.10 95% (C.I) (1.01-1.20), P = 0.026] in female subjects were found to be independent determinants of NAFLD after adjusting the BMI and TG. Serum leptin seems to have an association with NAFLD both in male and female prediabetic subjects and this association in turn, is mediated by insulin secretory dysfunction and insulin resistance among these subjects.
脂肪组织衍生的激素瘦素通过对胰岛素分泌和胰岛素敏感性的影响，在葡萄糖耐量中发挥功能性作用，而胰岛素分泌和胰岛素敏感性也是非酒精性脂肪性肝病（NAFLD）的危险因素。本研究探讨了孟加拉国糖尿病前期受试者血清瘦素和胰岛素指标与NAFLD的性别特异性关联。在横断面分析设计下，共调查了110名接受超声检查的糖尿病前期受试者，年龄在25 - 68岁之间，其中男性占57.3%（55.6%非NAFLD和44.4% NAFLD），女性占42.7%（57.4%非NAFLD和42.6% NAFLD）。通过稳态模型评估（HOMA）计算胰岛素分泌功能（HOMA%B）和胰岛素敏感性（HOMA%S）。在患有NAFLD的男性糖尿病前期受试者中，血清瘦素与空腹胰岛素（r = 0.530，P = 0.004）、餐后胰岛素（r = 0.384，P = 0.042）和HOMA-IR（r = 0.541，P = 0.003）呈显著正相关，与HOMA%S（r = -0.388，P = 0.046）和HOMA%B（r = -0.356，P = 0.039）呈显著负相关。在多元线性回归分析中，在调整了体重指数（BMI）、甘油三酯（TG）和HOMA%B的影响后，对数转换后的瘦素在患有NAFLD的男性受试者中与HOMA-IR呈显著正相关（β = 0.706，P <0.001）。在二元逻辑回归分析中，在调整了BMI和TG后，仅男性受试者中的对数瘦素[比值比1.29 95%（置信区间）（1.11 - 1.51），P = 0.001]以及女性受试者中的HOMA%B[比值比0.94 95%（置信区间）（0.89 - 0.98），P = 0.012]、HOMA-IR[比值比
