Departamento de Morfología y Biología Celular, Facultad de Medicina y Ciencias de la Salud, University of Oviedo, Spain; Instituto Universitario Oncológico del Principado de Asturias (IUOPA), Oviedo, Spain.
Departamento de Morfología y Biología Celular, Facultad de Medicina y Ciencias de la Salud, University of Oviedo, Spain.
Free Radic Biol Med. 2015 Aug;85:45-55. doi: 10.1016/j.freeradbiomed.2015.04.001. Epub 2015 Apr 10.
The role of manganese-dependent superoxide dismutase (SOD2/MnSOD) during tumor progression has been studied for several decades with controversial results. While SOD2 downregulation was initially associated with tumor initiation and was proposed as a tumor suppressor gene, recent studies have reported that SOD2 might favor tumor progression and dissemination. To our knowledge this is the first time that changes in SOD2 expression in three different types of tumors, i.e., prostate, lung, and colon cancer, are studied by analyzing both SOD2 mRNA and protein levels in a total of 246 patients' samples. In prostate samples, SOD2 protein levels were also increased, especially in middle stage tumors. In the case of colon and lung tumors both mRNA and protein SOD2 levels were increased in malignant tissues compared to those in nontumor samples. More importantly, all metastases analyzed showed increased levels of SOD2 when compared to those of normal primary tissue and healthy adjacent tissue. Together, these results suggest that a common redox imbalance in these three types of tumor occurs at intermediate stages which then might favor migration and invasion, leading to a more aggressive cancer type. Consequently, the ratios SOD2/catalase and SOD2/Gpx1 could be considered as potential markers during progression from tumor growth to metastasis.
几十年来，人们一直在研究锰依赖性超氧化物歧化酶（SOD2/MnSOD）在肿瘤进展过程中的作用，但结果存在争议。虽然 SOD2 的下调最初与肿瘤的发生有关，并被认为是一种肿瘤抑制基因，但最近的研究表明，SOD2 可能有利于肿瘤的进展和扩散。据我们所知，这是第一次通过分析总共 246 名患者样本中的 SOD2 mRNA 和蛋白质水平，研究三种不同类型的肿瘤（前列腺癌、肺癌和结肠癌）中 SOD2 表达的变化。在前列腺样本中，SOD2 蛋白水平也升高了，尤其是在中期肿瘤中。在结肠癌和肺癌中，与非肿瘤样本相比，恶性组织中的 SOD2 mRNA 和蛋白水平均升高。更重要的是，与正常原发组织和健康相邻组织相比，所有分析的转移灶中 SOD2 水平均升高。这些结果表明，这三种类型的肿瘤在中间阶段发生了共同的氧化还原失衡，这可能有利于迁移和侵袭，导致更具侵袭性的癌症类型。因此，SOD2/过氧化氢酶和 SOD2/谷胱甘肽过氧化物酶 1 的比值可以被认为是肿瘤生长到转移过程中的潜在标志物。
