Kennedy J D, Sutton R C, Conley F K
Stanford University School of Medicine, California.
Neurosurgery. 1989 Nov;25(5):709-14. doi: 10.1097/00006123-198911000-00004.
Using KHT tumor in a mouse metastatic tumor model, we examined the effect of intracerebral and/or intraperitoneal injections of Corynebacterium parvum on the growth of metastatic brain tumor and the development of an inflammatory response in the central nervous system (CNS). C. parvum given intraperitoneally had no effect on the development and growth of CNS tumor, but did prolong the survival of mice by inhibiting the growth of systemic metastatic tumor, which was the cause of death in our tumor model. Mice that received intracerebral injections of C. parvum exhibited significantly decreased growth of metastatic brain tumor, as compared with mice that received intracerebral injections of saline, whether or not they had received C. parvum intraperitoneally. In addition, the brains of mice that received C. parvum intracerebrally exhibited an inflammatory response that was minimal or absent in the brains of control mice. Our results suggest that if immunotherapeutic agents can be delivered to the CNS and cause an inflammatory response, they can be effective against CNS metastases.
在小鼠转移性肿瘤模型中使用KHT肿瘤，我们研究了脑内和/或腹腔注射短小棒状杆菌对转移性脑肿瘤生长及中枢神经系统（CNS）炎症反应发展的影响。腹腔注射短小棒状杆菌对CNS肿瘤的发展和生长没有影响，但通过抑制全身转移性肿瘤的生长确实延长了小鼠的生存期，而全身转移性肿瘤是我们肿瘤模型中的致死原因。与接受脑内注射生理盐水的小鼠相比，无论是否接受过腹腔注射短小棒状杆菌，接受脑内注射短小棒状杆菌的小鼠转移性脑肿瘤生长均显著减缓。此外，脑内接受短小棒状杆菌注射的小鼠大脑出现了炎症反应，而对照小鼠大脑中的炎症反应则很轻微或不存在。我们的结果表明，如果免疫治疗药物能够递送至CNS并引发炎症反应，那么它们可能对CNS转移瘤有效。
