Cai Z Z, Xu L B, Cai J L, Wang J S, Zhou B, Hu H
Department of Gastroenterology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Department of General Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Genet Mol Res. 2015 Mar 30;14(1):2707-15. doi: 10.4238/2015.March.30.31.
Pancreatic ductal adenocarcinoma (PDAC) is charac-terized by a poor prognosis and high mortality rate. In this study, we investigated the expression of Rab23 in non-tumor pancreatic tissues and PDACs via immunohistochemistry. Rab23 was found in 39 of 58 (67.2%) and in 11 of 30 (36.7%) of the PDAC and non-tumor pan-creatic tissue samples (P = 0.0073), respectively. There were signifi-cant correlations between Rab23 expression and unfavorable variables, including cancer differentiation level (P = 0.0089), lymph nodal (P = 0.0099), and distant metastases (P = 0.0173). Inactivation with small interfering RNA against Rab23 in the human pancreatic cancer cell line Panc-1 inhibited the migration and invasive potential of the cells. Our data provide new insight into the essential role of Rab23 in PDAC inva-sion and metastasis and suggest that Rab23 expression is a useful indi-cator of metastatic potential; hence, it may be a new therapeutic target for this common malignancy.
胰腺导管腺癌（PDAC）的特点是预后差和死亡率高。在本研究中，我们通过免疫组织化学研究了Rab23在非肿瘤胰腺组织和PDAC中的表达。Rab23分别在58个PDAC样本中的39个（67.2%）和30个非肿瘤胰腺组织样本中的11个（36.7%）中被发现（P = 0.0073）。Rab23表达与不良变量之间存在显著相关性，包括癌症分化程度（P = 0.0089）、淋巴结转移（P = 0.0099）和远处转移（P = 0.0173）。在人胰腺癌细胞系Panc-1中用针对Rab23的小干扰RNA使其失活，抑制了细胞的迁移和侵袭能力。我们的数据为Rab23在PDAC侵袭和转移中的重要作用提供了新的见解，并表明Rab23表达是转移潜能的一个有用指标；因此，它可能是这种常见恶性肿瘤的一个新的治疗靶点。
