Chang Junkai, Xu Weibo, Liu Guangchao, Du Xinyi, Li Xiaodong
Department of Urology, Huaihe Hospital of Henan University, Kaifeng, Henan Province, P.R. China.
Oncol Res. 2017 Jan 26;25(2):241-248. doi: 10.3727/096504016X14742891049118.
Rab23, a novel member of the Rab GTPase family, was found to be implicated in the progression of some human cancers. However, what role Rab23 plays in prostate cancer (PCa) remains to be illustrated. In the present study, we investigated the expression pattern and roles of Rab23 in PCa. The study results showed that Rab23 was upregulated in PCa tissues and cell lines. Moreover, downregulation of Rab23 remarkably suppressed the proliferation, migration, and invasion of PCa cells. In addition, downregulation of Rab23 significantly downregulated the protein expression levels of Shh and Gli1. Furthermore, we found that the Gli1 inhibitor GANT-61 greatly enhanced the suppressive effect of Rab23 downregulation on PCa cells. In conclusion, we suggested Rab23 as a potential therapeutic target for PCa treatment.
Rab23是Rab GTPase家族的一个新成员，被发现与一些人类癌症的进展有关。然而，Rab23在前列腺癌（PCa）中发挥何种作用仍有待阐明。在本研究中，我们调查了Rab23在PCa中的表达模式及其作用。研究结果表明，Rab23在PCa组织和细胞系中上调。此外，Rab23的下调显著抑制了PCa细胞的增殖、迁移和侵袭。此外，Rab23的下调显著降低了Shh和Gli1的蛋白表达水平。此外，我们发现Gli1抑制剂GANT-61大大增强了Rab23下调对PCa细胞的抑制作用。总之，我们建议将Rab23作为PCa治疗的潜在治疗靶点。
