Department of Radiology, Stanford University & Stanford University Medical Center, Stanford, CA 94305, USA.
Nanomedicine (Lond). 2015;10(6):993-1018. doi: 10.2217/nnm.14.203.
Current neuroimaging provides detailed anatomic and functional evaluation of brain tumors, allowing for improved diagnostic and prognostic capabilities. Some challenges persist even with today's advanced imaging techniques, including accurate delineation of tumor margins and distinguishing treatment effects from residual or recurrent tumor. Ultrasmall superparamagnetic iron oxide nanoparticles are an emerging tool that can add clinically useful information due to their distinct physiochemical features and biodistribution, while having a good safety profile. Nanoparticles can be used as a platform for theranostic drugs, which have shown great promise for the treatment of CNS malignancies. This review will provide an overview of clinical ultrasmall superparamagnetic iron oxides and how they can be applied to the diagnostic and therapeutic neuro-oncologic setting.
目前的神经影像学为脑肿瘤提供了详细的解剖学和功能评估，从而提高了诊断和预后能力。即使采用当今先进的成像技术，仍存在一些挑战，包括准确勾画肿瘤边界，以及区分治疗效果与残留或复发性肿瘤。超顺磁性氧化铁纳米颗粒是一种新兴工具，由于其独特的物理化学特性和生物分布，可提供有临床价值的信息，同时具有良好的安全性。纳米颗粒可用作治疗药物的平台，在治疗中枢神经系统恶性肿瘤方面显示出巨大的潜力。本文将综述临床超顺磁性氧化铁纳米颗粒及其在神经肿瘤学诊断和治疗中的应用。
