Periodontol 2000. 2015 Jun;68(1):83-98. doi: 10.1111/prd.12057.
Clinical studies have evaluated the effect of conventional periodontal surgical therapy. In general, although some clinical gain in tissue support may be attained, these therapies do not support regeneration of the periodontal attachment. Even though the biological possibility of periodontal regeneration has been demonstrated, the clinical application of this intrinsic potential appears difficult to harness; thus also conceptually most intriguing candidate protocols face clinical challenges. In this review, we explore the bioclinical principles, condiciones sine quibus non, that unleash the innate potential of the periodontium to achieve clinically meaningful periodontal regeneration (i.e. space-provision, wound stability and conditions for primary intention healing). Moreover, limiting factors and detrimental practices that may compromise clinical and biological outcomes are reviewed, as is tissue management in clinical settings.
临床研究已经评估了传统牙周手术治疗的效果。一般来说，尽管可能获得一些组织支持的临床增益，但这些治疗并不能支持牙周附着的再生。尽管已经证明了牙周再生的生物学可能性，但这种内在潜力的临床应用似乎难以利用；因此，即使是最具吸引力的概念性候选方案也面临临床挑战。在这篇综述中，我们探讨了释放牙周固有潜力以实现有临床意义的牙周再生（即空间提供、伤口稳定性和一期愈合条件）的生物临床原则和必要条件。此外，还回顾了可能影响临床和生物学结果的限制因素和有害实践，以及临床环境中的组织管理。
