Araki Tetsuro, Nishino Mizuki, Zazueta Oscar E, Gao Wei, Dupuis Josée, Okajima Yuka, Latourelle Jeanne C, Rosas Ivan O, Murakami Takamichi, O'Connor George T, Washko George R, Hunninghake Gary M, Hatabu Hiroto
Department of Radiology, Center for Pulmonary Functional Imaging, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02215, USA; Department of Radiology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
Department of Radiology, Center for Pulmonary Functional Imaging, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02215, USA.
Eur J Radiol. 2015 Jul;84(7):1413-8. doi: 10.1016/j.ejrad.2015.03.010. Epub 2015 Mar 18.
To investigate the prevalence and distribution of paraseptal emphysema on chest CT images in the Framingham Heart Study (FHS) population, and assess its impact on pulmonary function. Also pursued was the association with interstitial lung abnormalities.
We assessed 2633 participants in the FHS for paraseptal emphysema on chest CT. Characteristics of the participants, including age, sex, smoking status, clinical symptoms, and results of pulmonary function tests, were compared between those with and without paraseptal emphysema. The association between paraseptal emphysema and interstitial lung abnormalities was investigated.
Of the 2633 participants, 86 (3%) had pure paraseptal emphysema (defined as paraseptal emphysema with no other subtypes of emphysema other than paraseptal emphysema or a very few centrilobular emphysema involved) in at least one lung zone. The upper zone of the lungs was almost always involved. Compared to the participants without paraseptal emphysema, those with pure paraseptal emphysema were significantly older, and were more frequently male and smokers (mean 64 years, 71% male, mean 36 pack-years, P<0.001) and had significantly decreased FEV1/FVC% (P=0.002), and diffusion capacity of carbon monoxide (DLCO) (P=0.002). There was a significant association between pure paraseptal emphysema and interstitial lung abnormalities (P<0.001).
The prevalence of pure paraseptal emphysema was 3% in the FHS population, predominantly affects the upper lung zone, and contributes to decreased pulmonary function. Cigarette smoking, aging, and male gender were the factors associated with the presence of paraseptal emphysema. Significant association between paraseptal emphysema and interstitial lung abnormalities was observed.
在弗雷明汉心脏研究（FHS）人群中，调查胸部CT图像上肺间隔旁肺气肿的患病率和分布情况，并评估其对肺功能的影响。同时探讨其与间质性肺异常的关联。
我们对FHS中的2633名参与者进行胸部CT检查，以评估肺间隔旁肺气肿情况。比较有和没有肺间隔旁肺气肿的参与者的特征，包括年龄、性别、吸烟状况、临床症状和肺功能测试结果。研究肺间隔旁肺气肿与间质性肺异常之间的关联。
在2633名参与者中，86名（3%）至少在一个肺区有单纯性肺间隔旁肺气肿（定义为除肺间隔旁肺气肿外无其他肺气肿亚型，或仅涉及极少数小叶中心型肺气肿）。肺部上叶几乎总是受累。与没有肺间隔旁肺气肿的参与者相比，患有单纯性肺间隔旁肺气肿的参与者年龄显著更大，男性和吸烟者更常见（平均64岁，71%为男性，平均吸烟量36包年，P<0.001），且第一秒用力呼气容积/用力肺活量百分比（FEV1/FVC%）和一氧化碳弥散量（DLCO）显著降低（P=0.002）。单纯性肺间隔旁肺气肿与间质性肺异常之间存在显著关联（P<0.001）。
在FHS人群中，单纯性肺间隔旁肺气肿的患病率为3%，主要影响肺上叶，并导致肺功能下降。吸烟、衰老和男性性别是与肺间隔旁肺气肿存在相关的因素。观察到肺间隔旁肺气肿与间质性肺异常之间存在显著关联。
