Graham E A M
Forensic Pathology Unit, University of Leicester, Robert Kilpatrick Building, Leicester Royal Infirmary, Leicester, LE2 7LX, UK,
Forensic Sci Med Pathol. 2007 Sep;3(3):221-5. doi: 10.1007/s12024-007-9009-5. Epub 2007 Oct 11.
The rapid development, success, and occasional failures of forensic DNA profiling are highly publicised, and as a consequence are well known to the scientific and public communities alike. Over the same period of time that forensic DNA typing has accelerated onto the scene, another related discipline has been born and has made equally, or perhaps, even more groundbreaking achievements in the same arena; that is the science of (bio)molecular archaeology. This review describes the extreme complications of ancient DNA analysis and highlights some of the major achievements that have been accomplished in this field. The nature of DNA degradation and possible solutions to this problem are discussed.
法医DNA分析的迅速发展、成功以及偶尔的失败都得到了高度宣传,因此科学界和公众都对其了如指掌。在法医DNA分型迅速兴起的同一时期,另一个相关学科应运而生,并在同一领域取得了同样具有开创性,甚至可能更具开创性的成就;这就是(生物)分子考古学。这篇综述描述了古代DNA分析的极端复杂性,并强调了该领域已经取得的一些主要成就。文中还讨论了DNA降解的性质以及针对这一问题可能的解决办法。