El-Hennawi D M, Ahmed M R, Farid A M, Al Murtadah A M
Otolaryngology Unit,Faculty of Medicine,Suez Canal University,Ismailia,Egypt.
J Laryngol Otol. 2015 May;129(5):462-7. doi: 10.1017/S0022215115000456. Epub 2015 Apr 14.
Acute rhinosinusitis arises as a consequence of viral rhinitis, and bacterial infection can subsequently occur. Intranasal antibiotics as an adjunct to corticosteroids usually demonstrate the greatest symptom relief.
We wanted to clinically evaluate the effects of a topical antibiotic and steroid combination administered intranasally, versus an oral antibiotic alone when treating acute rhinosinusitis.
Forty patients with acute bacterial rhinosinusitis were divided into two groups. Group A received an antibiotic and steroid combination (ofloxacin 0.26 per cent and dexamethasone 0.053 per cent nasal drops) for 10 days, administered intranasally (5 drops in each nostril/8 hours). Group B, the control group, received an oral antibiotic alone (amoxicillin 90 mg/kg).
Eight hours after commencing treatment, facial pain was more severe in group B and nasal obstruction was reduced in both groups. Ten days after commencing treatment, anterior nasal discharge was 0.15 per cent in group A and absent in group B.
The application of a topical antibiotic and steroid combination into the nasal cavity is an effective way of treating uncomplicated, acute bacterial rhinosinusitis with the theoretical advantages of easy administration, high local drug concentration and minimal systemic adverse effects.
急性鼻窦炎是由病毒性鼻炎引发的，随后可能会发生细菌感染。鼻内使用抗生素作为皮质类固醇的辅助药物通常能最大程度缓解症状。
我们想临床评估鼻内使用局部抗生素和类固醇组合与单独口服抗生素治疗急性鼻窦炎的效果。
40例急性细菌性鼻窦炎患者被分为两组。A组接受抗生素和类固醇组合（0.26%氧氟沙星和0.053%地塞米松滴鼻剂）治疗10天，通过鼻内给药（每侧鼻孔滴5滴/每8小时）。B组为对照组，仅接受口服抗生素（阿莫西林90mg/kg）。
开始治疗8小时后，B组面部疼痛更严重，两组鼻塞均减轻。开始治疗10天后，A组前鼻分泌物为0.15%，B组无分泌物。
鼻腔内应用局部抗生素和类固醇组合是治疗单纯性急性细菌性鼻窦炎的有效方法，具有给药方便、局部药物浓度高和全身不良反应最小的理论优势。
