黏着连接在新皮质发育中的作用。
The role of adherens junctions in the developing neocortex.
作者信息
Stocker Adam M, Chenn Anjen
机构信息
a Molecular Neurobiology Laboratory ; The Salk Institute ; La Jolla , CA USA.
出版信息
Cell Adh Migr. 2015;9(3):167-74. doi: 10.1080/19336918.2015.1027478.
Abstract
The disproportional enlargement of the neocortex through evolution has been instrumental in the success of vertebrates, in particular mammals. The neocortex is a multilayered sheet of neurons generated from a simple proliferative neuroepithelium through a myriad of mechanisms with substantial evolutionary conservation. This developing neuroepithelium is populated by progenitors that can generate additional progenitors as well as post-mitotic neurons. Subtle alterations in the production of progenitors vs. differentiated cells during development can result in dramatic differences in neocortical size. This review article will examine how cadherin adhesion proteins, in particular α-catenin and N-cadherin, function in regulating the neural progenitor microenvironment, cell proliferation, and differentiation in cortical development.
摘要
在进化过程中，新皮层不成比例的扩大对脊椎动物尤其是哺乳动物的成功起到了重要作用。新皮层是一层多层神经元薄片，它由简单的增殖性神经上皮通过众多具有显著进化保守性的机制产生。这个正在发育的神经上皮中存在着祖细胞，这些祖细胞能够产生更多的祖细胞以及有丝分裂后的神经元。在发育过程中，祖细胞与分化细胞产生的细微变化可能会导致新皮层大小出现显著差异。这篇综述文章将探讨钙黏蛋白黏附蛋白，特别是α - 连环蛋白和N - 钙黏蛋白，在调节神经祖细胞微环境、细胞增殖以及皮层发育中的分化方面所发挥的作用。
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